TY - JOUR AU - Shiota, Asuka AU - Shimabukuro, Michio AU - Fukuda, Daiju AU - Soeki, Takeshi AU - Sato, Hiromi AU - Uematsu, Etsuko AU - Hirata, Yoichiro AU - Kurobe, Hirotsugu AU - Maeda, Norikazu AU - Sakaue, Hiroshi AU - Masuzaki, Hiroaki AU - Shimomura, Iichiro AU - Sata, Masataka PY - 2012 DA - 2012/11/08 TI - Telmisartan ameliorates insulin sensitivity by activating the AMPK/SIRT1 pathway in skeletal muscle of obese db/db mice JO - Cardiovascular Diabetology SP - 139 VL - 11 IS - 1 AB - Telmisartan is a well-established angiotensin II type 1 receptor blocker that improves insulin sensitivity in animal models of obesity and insulin resistance, as well as in humans. Telmisartan has been reported to function as a partial agonist of the peroxisome proliferator-activated receptor (PPAR) γ, which is also targeted by the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase (SIRT1). Here, we investigated the pathways through which telmisartan acts on skeletal muscle, in vitro as well as in vivo. SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-11-139 DO - 10.1186/1475-2840-11-139 ID - Shiota2012 ER -