Association between 9p21 genetic variants and mortality risk in a prospective cohort of patients with type 2 diabetes (ZODIAC-15)

Table 2 Cox proportional hazard analyses for total and cardiovascular mortality among type 2 diabetes patients according to the rs10811661 and rs10757278 genotypes after a median follow-up of 9.5 years

Genotype	N of patients (deceased)	HR total mortality^a	HR total mortality^b	HR CV mortality^a	HR CV mortality^b
rs10811661
CT/CC	264 (113)	1	1	1	1
TT	635 (238)	0.79 (0.63 -0.99)	0.74 (0.59-0.93)	0.82 (0.57-1.17)	0.76 (0.52-1.10)
Missing	15 (7)	p= 0.04	p= 0.01	P=0.28	p=0.15
rs10757278
AA/AG	704 (266)	1	1		1
GG	188 (81)	1.33 (1.04-1.71)	1.31 (1.01-1.70)	1.27 (0.87-1.72)	1.18 (0.80-1.78)
Missing	22 (11)	p =0.02	p =0.04	P=0.20	p=0.44

^a Corrected for age and sex according to model 1, ^b corrected for 11 baseline variables (age, gender, diabetes duration, history of macrovascular complications, smoking status, BMI, Hba1c, systolic blood pressure, serum creatinine, total cholesterol-HDL ratio, and urinary albumin-to-creatinine ratio) according to model 2.

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