Table 3 Association between the FTO, the MC4R and the combined score ( FTO and MC4R polymorphisms) and type 2 diabetes
Model 1 | Model 2 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Adherence to the Mediterranean diet | Adherence to the Mediterranean diet | |||||||||
Low (<9 points) | High (>=9 points) | P2interaction | Low (<9 points) | High (>=9 points) | P2interaction | |||||
OR | 95% CI | OR | 95% CI | Gene x AMD | OR | 95% CI | OR | 95% CI | Gene x AMD | |
FTO rs9939609 (n=7,052) | 0.039 | 0.039 | ||||||||
TT | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | ||
TA + AA | 1.21 | (1.03-1.40) | 0.97 | (0.85-1.13) | 1.20 | (1.03-1.40) | 0.97 | (0.85-1.12) | ||
P1=0.019 | P1=0.673 | P1=0.020 | P1=0.743 | |||||||
MC4R rs17782313 (n=7,019) | 0.009 | 0.009 | ||||||||
TT | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | ||
TC + CC | 1.17 | (1.01-1.36) | 0.89 | (0.78-1.02) | 1.17 | (1.01-1.36) | 0.89 | (0.78-1.02) | ||
P1=0.035 | P1=0.097 | P1=0.036 | P1=0.102 | |||||||
Aggregate score ( FTO / MC4R ) | 0.006 | 0.006 | ||||||||
TT and TT (0) | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) | ||
TA or TC (1) | 1.26 | (1.05-1.56) | 0.89 | (0.75-1.07) | 1.27 | (1.06-1.56) | 0.89 | (0.75-1.07) | ||
TA and TC or AA or CC (2) | 1.29 | (1.05-1.59) | 0.96 | (0.79-1.16) | 1.29 | (1.05-1.59) | 0.96 | (0.79-1.17) | ||
Otherwise (3 or 4 variants) | 1.45 | (1.10-1.93) | 0.86 | (0.66-1.12) | 1.45 | (1.09-1.92) | 0.87 | (0.69-1.13) | ||
P1=0.024 | P1=0.532 | P1=0.024 | P1=0.513 | |||||||
Variant allele effects** | 0.012 | 0.012 | ||||||||
(Per variant allele: 1,2,3,or 4) | 1.12 | (1.03-1.21) | 0.97 | (0.91-1.05) | 1.12 | (1.03-1.21) | 0.97 | (0.91-1.05) | ||
P1=0.005 | P1=0.475 | P1=0.006 | P1=0.532 | |||||||