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Table 3 Association between the FTO, the MC4R and the combined score ( FTO and MC4R polymorphisms) and type 2 diabetes

From: Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

  Model 1   Model 2  
  Adherence to the Mediterranean diet   Adherence to the Mediterranean diet  
  Low (<9 points) High (>=9 points) P2interaction Low (<9 points) High (>=9 points) P2interaction
  OR 95% CI OR 95% CI Gene x AMD OR 95% CI OR 95% CI Gene x AMD
FTO rs9939609 (n=7,052)      0.039      0.039
TT 1.00 (reference) 1.00 (reference)   1.00 (reference) 1.00 (reference)  
TA + AA 1.21 (1.03-1.40) 0.97 (0.85-1.13)   1.20 (1.03-1.40) 0.97 (0.85-1.12)  
  P1=0.019 P1=0.673   P1=0.020 P1=0.743  
MC4R rs17782313 (n=7,019)      0.009      0.009
TT 1.00 (reference) 1.00 (reference)   1.00 (reference) 1.00 (reference)  
TC + CC 1.17 (1.01-1.36) 0.89 (0.78-1.02)   1.17 (1.01-1.36) 0.89 (0.78-1.02)  
  P1=0.035 P1=0.097   P1=0.036 P1=0.102  
Aggregate score ( FTO / MC4R )      0.006      0.006
TT and TT (0) 1.00 (reference) 1.00 (reference)   1.00 (reference) 1.00 (reference)  
TA or TC (1) 1.26 (1.05-1.56) 0.89 (0.75-1.07)   1.27 (1.06-1.56) 0.89 (0.75-1.07)  
TA and TC or AA or CC (2) 1.29 (1.05-1.59) 0.96 (0.79-1.16)   1.29 (1.05-1.59) 0.96 (0.79-1.17)  
Otherwise (3 or 4 variants) 1.45 (1.10-1.93) 0.86 (0.66-1.12)   1.45 (1.09-1.92) 0.87 (0.69-1.13)  
  P1=0.024 P1=0.532   P1=0.024 P1=0.513  
Variant allele effects**      0.012      0.012
(Per variant allele: 1,2,3,or 4) 1.12 (1.03-1.21) 0.97 (0.91-1.05)   1.12 (1.03-1.21) 0.97 (0.91-1.05)  
  P1=0.005 P1=0.475    P1=0.006  P1=0.532  
  1. Stratified multivariate* logistic regression analysis depending on the adherence to the Mediterranean diet (AMD).
  2. *: Models adjusted for sex, age, center, total energy intake and physical activity (Model 1). Model 2 was additionally adjusted for BMI.
  3. **: For the estimation of the variant allele effect, the score variable indicating the number of combined variant alleles (0, 1, 2 , 3 and 4) was considered as continuous.
  4. P1: P value obtained for the global effect of the polymorphism in the multivariate logistic regression models.
  5. P2: P value for the interaction term between adherence to the Mediterranean diet and the corresponding polymorphism in the logistic regression model.