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Table 2 Association between the FTO , the MC4R polymorphisms and the combined score ( FTO and MC4R ) and type 2 diabetes

From: Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

  Model 1 Model 2 Model 3
Genetic variants OR 95% CI OR 95% CI OR 95% CI
FTO rs9939609 (n=7,052)       
Genotypes       
TT 1.00 (reference) 1.00 (reference) 1.00 (reference)
TA+AA 1.08 (0.97-1.19) 1.07 (0.97-1.18) 1.07 (0.97-1.19)
  P=0.147 P=0.191 P=0.181
Variant allele effects**       
(Per A allele) 1.06 (0.99-1.14) 1.06 (0.98-1.13) 1.06 (0.98-1.13)
  P=0.079 P=0.118 P=0.111
MC4 R rs17782313 (n=7,019)       
TT 1.00 (reference) 1.00 (reference) 1.00 (reference)
TC+CC 1.01 (0.92-1.12) 1.01 (0.92-1.12) 1.01 (0.91-1.12)
  P=0.832 P=0.837 P=0.845
Variant allele effects**       
(Per C allele) 1.01 (0.93-1.10) 1.01 (0.93-1.09) 1.01 (0.93-1.09)
  P=0.808 P=0.817 P=0.800
Aggregate score ( FTO / MC4R )       
TT and TT (0) 1.00 (reference) 1.00 (reference) 1.00 (reference)
TA or TC (1) 1.06 (0.93-1.21) 1.06 (0.93-1.20) 1.06 (0.93-1.20)
TA and TC or AA or CC (2) 1.10 (0.96-1.27) 1.10 (0.96-1.27) 1.10 (0.96-1.27)
Otherwise (3 or 4 variants) 1.11 (0.92-1.34) 1.10 (0.90-1.32) 1.10 (0.91-1.33)
  P=0.553 P=0.572 P=0.553
Variant allele effects, score***       
(Per variant allele: 1,2,3,or 4) 1.04 (0.99-1.10) 1.04 (0.98-1.10) 1.04 (0.98-1.09)
  P=0.137  P=0.183 P=0.169
  1. Multivariate logistic Regression analysis.
  2. Model 1: Adjusted for sex, age and center.
  3. Model 2: Adjusted for sex, age, center, total energy intake and physical activity.
  4. Model 3: Adjusted for sex, age, center, total energy intake, physical activity and BMI.
  5. **: A variable indicating the number of variant alleles (0, 1 or 2) was created for both the FTO and the MC4R.
  6. ***: For the estimation as a score, a variable indicating the number of combined variant alleles was created (0, 1, 2, 3 or 4).
  7. P: P value obtained for the global effect of the polymorphism in the multivariate logistic regression models.