Table 2 Association between the FTO , the MC4R polymorphisms and the combined score ( FTO and MC4R ) and type 2 diabetes
Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
Genetic variants | OR | 95% CI | OR | 95% CI | OR | 95% CI |
FTO rs9939609 (n=7,052) | ||||||
Genotypes | ||||||
TT | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) |
TA+AA | 1.08 | (0.97-1.19) | 1.07 | (0.97-1.18) | 1.07 | (0.97-1.19) |
P=0.147 | P=0.191 | P=0.181 | ||||
Variant allele effects** | ||||||
(Per A allele) | 1.06 | (0.99-1.14) | 1.06 | (0.98-1.13) | 1.06 | (0.98-1.13) |
P=0.079 | P=0.118 | P=0.111 | ||||
MC4 R rs17782313 (n=7,019) | ||||||
TT | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) |
TC+CC | 1.01 | (0.92-1.12) | 1.01 | (0.92-1.12) | 1.01 | (0.91-1.12) |
P=0.832 | P=0.837 | P=0.845 | ||||
Variant allele effects** | ||||||
(Per C allele) | 1.01 | (0.93-1.10) | 1.01 | (0.93-1.09) | 1.01 | (0.93-1.09) |
P=0.808 | P=0.817 | P=0.800 | ||||
Aggregate score ( FTO / MC4R ) | ||||||
TT and TT (0) | 1.00 | (reference) | 1.00 | (reference) | 1.00 | (reference) |
TA or TC (1) | 1.06 | (0.93-1.21) | 1.06 | (0.93-1.20) | 1.06 | (0.93-1.20) |
TA and TC or AA or CC (2) | 1.10 | (0.96-1.27) | 1.10 | (0.96-1.27) | 1.10 | (0.96-1.27) |
Otherwise (3 or 4 variants) | 1.11 | (0.92-1.34) | 1.10 | (0.90-1.32) | 1.10 | (0.91-1.33) |
P=0.553 | P=0.572 | P=0.553 | ||||
Variant allele effects, score*** | ||||||
(Per variant allele: 1,2,3,or 4) | 1.04 | (0.99-1.10) | 1.04 | (0.98-1.10) | 1.04 | (0.98-1.09) |
P=0.137 | P=0.183 | P=0.169 | ||||