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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low

Figure 1

Adjusted means of fasting glucose concentrations depending on the FTO rs9939609 (A), MC4R rs17782313 (B) or their grouped aggregate score (C) and the level of folate intake (low <406μg/d or high ≥406μg/d) in non-diabetic subjects (n=3192 for the FTO rs9939609 and n=3180 for the MC4R rs17782313. P-int: P interaction values for the corresponding interaction terms between folate intake (as dichotomous) and the genetic variant obtained in the corresponding multivariate adjusted regression model including sex, age (as continuous), center, total energy intake (as continuous), physical activity (as dichotomous), folate intake (as dichotomous), the genetic variable (as categorical), and body mass index (as continuous) as covariates. *: P=0.043 for trend in the comparison of means in the multivariate adjusted model depending on the FTO rs9939609 genotype; **: P=0.027 for trend in the comparison of means in the adjusted model depending on the FTO/MC4R aggregate score. Error bars: SE of means.

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