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Table 4 Hazard ratios (HRs) of proteinuria for all-cause mortality and mortality due to expanded and non-expanded CVD-related causes stratified by eGFR status (n=6,523)

From: Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study

    Baseline mean eGFR HR (95% CI)   
   ≥90 (N=3,686)   60~89 (N=1,981)   15~59 (N=856)
Variables n All-cause mortality Expanded CVD-related mortality Non-expanded CVD-related mortality n All-cause mortality Expanded CVD-related mortality Non-expanded CVD-related mortality n All-cause mortality Expanded CVD-related mortality Non-expanded CVD-related mortality
Age-adjusted
Proteinuria
 No 2,787 1.00 1.00 1.00 1,225 1.00 1.00 1.00 254 1.00 1.00 1.00
 Yes 899 1.60** (1.17-2.19) 2.10** (1.29-3.41) 1.33 (0.88-2.01) 756 2.35*** (1.79-3.10) 2.47*** (1.64-3.72) 2.26*** (1.56-3.29) 602 2.51*** (1.72-3.67) 2.70*** (1.55-4.70) 2.32** (1.37-3.93)
Multivariate-adjusted1
Proteinuria
 No 2,787 1.00 1.00 1.00 1,225 1.00 1.00 1.00 254 1.00 1.00 1.00
 Yes 899 1.34 (0.97-1.86) 1.78* (1.08-2.93) 1.11 (0.73-1.70) 756 2.09*** (1.58-2.77) 2.18*** (1.44-3.32) 2.03*** (1.38-2.97) 602 2.31*** (1.56-3.40) 2.39** (1.36-4.21) 2.17** (1.27-3.72)
Multivariate-adjusted2
Proteinuria
 No 2,787 1.00 1.00 1.00 1,225 1.00 1.00 1.00 254 1.00 1.00 1.00
 Yes 899 1.17 (0.83-1.66) 1.40 (0.80-3.46) 1.02 (0.65-1.60) 756 1.92*** (1.43-2.58) 1.96** (1.27-3.03) 1.93** (1.30-2.87) 602 2.37*** (1.60-3.52) 2.41** (1.36-4.28) 2.29** (1.33-3.95)
  1. Multivariate-adjusted1 age, duration of diabetes, smoking, alcohol drinking, exercising, hypertension, hypertension drug treatment, obesity, hyperlipidemia and type of DM treatment and HbA1C. Multivariate-adjusted2 DKA, HHNK, severe hypoglycemia, stroke, myocardial infarction, peripheral neuropathy, intermittent claudication and neuropathy in addition to variables in model 1.
  2. *:p<0.05; **:p<0.01; ***:p<0.001.