Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study

Table 4 Hazard ratios (HRs) of proteinuria for all-cause mortality and mortality due to expanded and non-expanded CVD-related causes stratified by eGFR status (n=6,523)

						Baseline mean eGFR	HR (95% CI)
		≥90 (N=3,686)				60~89 (N=1,981)				15~59 (N=856)
Variables	n	All-cause mortality	Expanded CVD-related mortality	Non-expanded CVD-related mortality	n	All-cause mortality	Expanded CVD-related mortality	Non-expanded CVD-related mortality	n	All-cause mortality	Expanded CVD-related mortality	Non-expanded CVD-related mortality
Age-adjusted
Proteinuria
No	2,787	1.00	1.00	1.00	1,225	1.00	1.00	1.00	254	1.00	1.00	1.00
Yes	899	1.60** (1.17-2.19)	2.10** (1.29-3.41)	1.33 (0.88-2.01)	756	2.35*** (1.79-3.10)	2.47*** (1.64-3.72)	2.26*** (1.56-3.29)	602	2.51*** (1.72-3.67)	2.70*** (1.55-4.70)	2.32** (1.37-3.93)
Multivariate-adjusted¹
Proteinuria
No	2,787	1.00	1.00	1.00	1,225	1.00	1.00	1.00	254	1.00	1.00	1.00
Yes	899	1.34 (0.97-1.86)	1.78* (1.08-2.93)	1.11 (0.73-1.70)	756	2.09*** (1.58-2.77)	2.18*** (1.44-3.32)	2.03*** (1.38-2.97)	602	2.31*** (1.56-3.40)	2.39** (1.36-4.21)	2.17** (1.27-3.72)
Multivariate-adjusted²
Proteinuria
No	2,787	1.00	1.00	1.00	1,225	1.00	1.00	1.00	254	1.00	1.00	1.00
Yes	899	1.17 (0.83-1.66)	1.40 (0.80-3.46)	1.02 (0.65-1.60)	756	1.92*** (1.43-2.58)	1.96** (1.27-3.03)	1.93** (1.30-2.87)	602	2.37*** (1.60-3.52)	2.41** (1.36-4.28)	2.29** (1.33-3.95)

Multivariate-adjusted¹ age, duration of diabetes, smoking, alcohol drinking, exercising, hypertension, hypertension drug treatment, obesity, hyperlipidemia and type of DM treatment and HbA₁C. Multivariate-adjusted² DKA, HHNK, severe hypoglycemia, stroke, myocardial infarction, peripheral neuropathy, intermittent claudication and neuropathy in addition to variables in model 1.
*:p<0.05; **:p<0.01; ***:p<0.001.

ISSN: 1475-2840