Table 3 Hazard ratios (HRs) of all-cause mortality and mortality due to expanded and non-expanded CVD-related causes according to clinical stage of time-dependent annual mean eGFR stratified by proteinuria status (n=6,523)

2787

-

-

-

899

-

1225

1.02 (0.75-1.39)

1.16 (0.72-1.86)

0.93 (0.62-1.40)

756

1.42 (1.03-1.96)*

1.62 (0.97-2.71)

1.31 (0.86-2.00)

254

2.22 (1.56-3.18)***

2.20 (1.26-3.83)**

2.28 (1.43-3.63)***

602

2.51 (1.86-3.39)***

3.36 (2.11-5.37)***

1.99 (1.34-2.96)***

<0.001

0.01

0.009

<0.001

<0.001

<0.001

2787

-

-

-

899

-

1225

1.13 (0.82-1.54)

1.33 (0.82-2.16)

1.00 (0.66-1.52)

756

1.56 (1.12-2.16)**

1.76 (1.05-2.95)*

1.45 (0.94-2.22)

254

2.46 (1.69-3.57)***

2.62 (1.47-4.70)**

2.39 (1.46-3.89)***

602

2.58 (1.90-3.51)***

3.28 (2.04-5.29)***

2.14 (1.42-3.22)***

<0.001

0.003

0.005

<0.001

<0.001

<0.001

2787

-

-

-

899

-

-

-

1225

1.11 (0.81-1.52)

1.28 (0.79-2.08)

1.01 (0.67-1.53)

756

1.53 (1.10-2.12)*

1.70 (1.02-2.86)*

1.43 (0.94-2.20)

254

2.23 (1.51-3.30)***

1.98 (1.06-3.69)*

2.47 (1.49-4.10)***

602

2.49 (1.83-3.39)***

3.15 (1.96-5.09)***

2.06(1.37-3.12)***

<0.001

0.04

0.006

<0.001

<0.001

<0.001