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Table 2 Hazard ratios (HRs) of all-cause mortality and mortality due to expanded and non-expanded CVD-related causes based on the clinical stage of the time-dependent annual mean eGFR

From: Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study

Variables All-cause mortality P for trend Expanded CVD-related mortality P for trend Non-expanded CVD-related mortality P for trend
  HR (95% CI)   HR (95% CI)   HR (95% CI)  
Age-adjusted       
Annual mean eGFR (mL/min/1.73m2) <0.001   <0.001   <0.001
 ≥90 1.00   1.00   1.00  
 60~89 1.23 (0.99-1.53)   1.41 (1.00-2.00)*   1.13 (0.85-1.51)  
 15~59 2.37 (1.90-2.97)***   2.90 (2.07-4.10)***   2.04 (1.51-2.75)***  
Proteinuria 1.83 (1.53-2.19)***   1.99 (1.52-2.61)***   1.71 (1.35-2.18)***  
Multivariate-adjusted1       
Annual mean eGFR (mL/min/1.73m2) <0.001   <0.001   <0.001
 ≥90 1.00   1.00   1.00  
 60~89 1.33 (1.07-1.66)*   1.55 (1.09-2.19)*   1.21 (0.90-1.62)  
 15~59 2.49 (1.98-3.14)***   3.01 (2.12-4.28)***   2.16 (1.59-2.94)***  
Proteinuria 1.62 (1.35-1.95)***   1.75 (1.33-2.31)***   1.53 (1.20-1.95)***  
Multivariate-adjusted2       
Annual mean eGFR (mL/min/1.73m2) <0.001   <0.001   <0.001
 ≥90 1.00   1.00   1.00  
 60~89 1.31 (1.05-1.63)*   1.50 (1.06-2.12)*   1.20 (0.90-1.62)  
 15~59 2.37 (1.88-2.99)***   2.74 (1.92-3.90)***   2.13 (1.56-2.91)***  
Proteinuria 1.55 (1.28-1.87)***   1.63 (1.22-2.16)***   1.49 (1.16-1.92)**  
  1. Multivariate-adjusted1 age, duration of diabetes, smoking, alcohol drinking, exercising, hypertension, hypertension drug treatment, obesity, hyperlipidemia, type of DM treatment, and HbA1C. Multivariate-adjusted2 DKA, HHNK, severe hypoglycemia, stroke, myocardial infarction, peripheral neuropathy, intermittent claudication, and neuropathy in addition to variables in model 1.
  2. *p<0.05; **p<0.01; ***p<0.001.