Skip to main content

Table 2 Hazard ratios (HRs) of all-cause mortality and mortality due to expanded and non-expanded CVD-related causes based on the clinical stage of the time-dependent annual mean eGFR

From: Joint relationship between renal function and proteinuria on mortality of patients with type 2 diabetes: The Taichung Diabetes Study

Variables

All-cause mortality

P for trend

Expanded CVD-related mortality

P for trend

Non-expanded CVD-related mortality

P for trend

 

HR (95% CI)

 

HR (95% CI)

 

HR (95% CI)

 

Age-adjusted

      

Annual mean eGFR (mL/min/1.73m2)

<0.001

 

<0.001

 

<0.001

 ≥90

1.00

 

1.00

 

1.00

 

 60~89

1.23 (0.99-1.53)

 

1.41 (1.00-2.00)*

 

1.13 (0.85-1.51)

 

 15~59

2.37 (1.90-2.97)***

 

2.90 (2.07-4.10)***

 

2.04 (1.51-2.75)***

 

Proteinuria

1.83 (1.53-2.19)***

 

1.99 (1.52-2.61)***

 

1.71 (1.35-2.18)***

 

Multivariate-adjusted1

      

Annual mean eGFR (mL/min/1.73m2)

<0.001

 

<0.001

 

<0.001

 ≥90

1.00

 

1.00

 

1.00

 

 60~89

1.33 (1.07-1.66)*

 

1.55 (1.09-2.19)*

 

1.21 (0.90-1.62)

 

 15~59

2.49 (1.98-3.14)***

 

3.01 (2.12-4.28)***

 

2.16 (1.59-2.94)***

 

Proteinuria

1.62 (1.35-1.95)***

 

1.75 (1.33-2.31)***

 

1.53 (1.20-1.95)***

 

Multivariate-adjusted2

      

Annual mean eGFR (mL/min/1.73m2)

<0.001

 

<0.001

 

<0.001

 ≥90

1.00

 

1.00

 

1.00

 

 60~89

1.31 (1.05-1.63)*

 

1.50 (1.06-2.12)*

 

1.20 (0.90-1.62)

 

 15~59

2.37 (1.88-2.99)***

 

2.74 (1.92-3.90)***

 

2.13 (1.56-2.91)***

 

Proteinuria

1.55 (1.28-1.87)***

 

1.63 (1.22-2.16)***

 

1.49 (1.16-1.92)**

 
  1. Multivariate-adjusted1 age, duration of diabetes, smoking, alcohol drinking, exercising, hypertension, hypertension drug treatment, obesity, hyperlipidemia, type of DM treatment, and HbA1C. Multivariate-adjusted2 DKA, HHNK, severe hypoglycemia, stroke, myocardial infarction, peripheral neuropathy, intermittent claudication, and neuropathy in addition to variables in model 1.
  2. *p<0.05; **p<0.01; ***p<0.001.