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Table 3 Oxidative stress parameters evaluated in cardiac tissue of control, OB, STZ and STZ-treated OB rats

From: Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms

 

NON-DIABETIC

DIABETIC

 

CTRL (n  = 12)

OB (n  = 6)

CTRL (n  = 14)

OB (n  = 14)

ROS (U.F./mg prot)

106.67 ± 2.08

106.54 ± 15.44

165.67 ± 15.40*

116.43 ± 18.02†

GSSG/GSH (%)

1.60 ± 1.00

1.64 ± 0.40

8.91 ± 2.60***

4.43 ± 3.20†

HNE (μM)

0.80 ± 0.08

0.83 ± 0.08

1.79 ± 0.12**

1.02 ± 0.17††

  1. Values are expressed as means ± SD. Statistical significance: * P < 0.05 vs ND-CTRL; ** P < 0.01 vs ND-CTRL; *** P < 0.005 vs ND-CTRL; † P < 0.05 vs DM-CTRL; †† P < 0.01 vs DM-CTRL.