Table 1 A. Basal values for cardiac contractility in papillary heart muscles of untreated and OB-treated non-diabetic rats and in untreated and OB-treated diabetic rats
From: Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms
A | Â | Â | Â | Â |
|---|---|---|---|---|
| Â | NON-DIABETIC | DIABETIC | ||
|  | CTRL ( n  = 6) | OB (n  = 5) | CTRL (n  = 6) | OB ( n  = 5) |
 T max (mN/mm2) | 50.3 ± 7.7 | 42.8 ± 8.4 | 13.4 ± 6.9*** | 60.2 ± 20.5†††|
+ dT/dt max (mN/s) | 15265 ± 1759 | 14043 ± 1527 | 5420 ± 847*** | 14688 ± 2165†††|
- dT/dt max (mN/s) | 7297 ± 874 | 6785 ± 645 | 4056 ± 953*** | 6333 ± 1135††|
  TPT (ms) | 133.3 ± 14.2 | 114.5 ± 13.6 | 111.9 ± 31.4 | 149.6 ± 9.0 |
 Duration (ms) | 379.5 ±48.7 | 353.5 ± 20.2 | 361.7 ± 75.4 | 407.6 ± 26.2 |
B Isoproterenol (1 μM) | ||||
| Â | NON-DIABETIC | DIABETIC | ||
|  | CTRL ( n  = 6) | OB ( n  = 5) | CTRL ( n  = 6) | OB ( n  = 5) |
  T max % | 189.7 ± 27.8 | 197.3 ± 48.0 | 123.8 ± 18.0** | 183.2 ± 22.7††|
 + dT/dt max % | 192.7 ± 40.6 | 205.0 ± 39.2 | 127.3 ± 16.8** | 190.0 ± 31.0††|
 - dT/dt max % | 250.3 ± 28.1 | 227.6 ± 28.4 | 126.0 ± 14.2*** | 187.6 ± 31.1††|
  TPT% | 85.0 ± 2.4 | 86.6 ± 5.9 | 97.8 ± 4.1*** | 90.8 ± 3.3††|
 Duration% | 83.3 ± 3.4 | 85.5 ± 10.6 | 95.6 ± 5.8 | 90.0 ± 6.8 |