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Table 1 A. Basal values for cardiac contractility in papillary heart muscles of untreated and OB-treated non-diabetic rats and in untreated and OB-treated diabetic rats

From: Obestatin induced recovery of myocardial dysfunction in type 1 diabetic rats: underlying mechanisms

A     
  NON-DIABETIC DIABETIC
  CTRL ( n  = 6) OB (n  = 5) CTRL (n  = 6) OB ( n  = 5)
T max (mN/mm2) 50.3 ± 7.7 42.8 ± 8.4 13.4 ± 6.9*** 60.2 ± 20.5†††
+ dT/dt max (mN/s) 15265 ± 1759 14043 ± 1527 5420 ± 847*** 14688 ± 2165†††
- dT/dt max (mN/s) 7297 ± 874 6785 ± 645 4056 ± 953*** 6333 ± 1135††
  TPT (ms) 133.3 ± 14.2 114.5 ± 13.6 111.9 ± 31.4 149.6 ± 9.0
Duration (ms) 379.5 ±48.7 353.5 ± 20.2 361.7 ± 75.4 407.6 ± 26.2
B Isoproterenol (1 μM)
  NON-DIABETIC DIABETIC
  CTRL ( n  = 6) OB ( n  = 5) CTRL ( n  = 6) OB ( n  = 5)
  T max % 189.7 ± 27.8 197.3 ± 48.0 123.8 ± 18.0** 183.2 ± 22.7††
+ dT/dt max % 192.7 ± 40.6 205.0 ± 39.2 127.3 ± 16.8** 190.0 ± 31.0††
- dT/dt max % 250.3 ± 28.1 227.6 ± 28.4 126.0 ± 14.2*** 187.6 ± 31.1††
  TPT% 85.0 ± 2.4 86.6 ± 5.9 97.8 ± 4.1*** 90.8 ± 3.3††
Duration% 83.3 ± 3.4 85.5 ± 10.6 95.6 ± 5.8 90.0 ± 6.8
  1. B. Effect of Iso (1 μM) on cardiac contractility. Value expressed as % variation respect to control (before Iso). Papillary muscles did not significantly differ in size among the different groups (diameter: 0.78 ± 0.08, 0.81 ± 0.12, 1.23 ± 0.15 and 1.18 ± 0.09 mm, respectively).
  2. Values are expressed as means ± SD. Statistical significance: ** P < 0.01vs ND-CTRL; *** P < 0.001 vs ND-CTRL; †† P < 0.01 vs DM-CTRL; ††† P < 0.001 vs DM-CTRL.