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Table 7 Correlation between genotypes or alleles and serum lipid levels in the overweight/obese subjects

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid Genotype/allele Unstandardized coefficient Std. cp error Standardized coefficient t P
TC ABCA-1 V825I all`ele 0.162 0.078 0.074 2.078 0.038
  LIPG 584C>T genotype 0.228 0.073 0.109 3.122 0.002
  LIPG 584C>T allele 0.251 0.084 0.105 2.993 0.003
  MTHFR 677C>T genotype 0.158 0.060 0.092 2.624 0.009
  MTHFR 677C>T allele 0.245 0.075 0.115 3.267 0.001
  MYLIP rs3757354 genotype −0.121 0.054 −0.082 −2.264 0.024
  PPARD +294T>C allele 0.222 0.083 0.096 2.666 0.008
  SCARB1 rs5888 allele −0.182 0.069 −0.095 −2.633 0.009
TG MTHFR 677C>T genotype 0.272 0.106 0.090 2.556 0.011
  PCSK9 E670G genotype 1.251 0.309 0.137 4.053 0.000
  PPARD +294T>C allele 0.675 0.179 0.133 3.763 0.000
  SCARB1 rs5888 genotype 0.232 0.099 0.084 2.337 0.020
HDL-C ABCA-1 V825I genotype −0.048 0.022 −0.077 −2.193 0.029
  LIPG 584C>T genotype 0.087 0.026 0.114 3.337 0.001
  LIPG 584C>T allele 0.068 0.030 0.078 2.270 0.024
  MTHFR 677C>T genotype 0.097 0.023 0.146 4.122 0.000
  MTHFR 677C>T allele 0.138 0.029 0.167 4.721 0.000
  PCSK9 E670G genotype −0.167 0.075 −0.076 −2.234 0.026
  SCARB1 rs5888 genotype −0.069 0.029 −0.084 −2.265 0.018
LDL-C ABCA-1 V825I genotype 0.134 0.040 0.119 3.308 0.001
  ABCA-1 V825I allele 0.228 0.061 0.134 3.726 0.000
  LIPG 584C>T genotype 0.115 0.054 0.076 2.106 0.035
  LIPG 584C>T allele 0.131 0.062 0.077 2.116 0.035
ApoA1 ABCA-1 V825I allele −0.044 0.020 −0.075 −2.138 0.033
  LIPG 584C>T genotype 0.036 0.018 0.071 2.038 0.042
  MTHFR 677C>T genotype 0.057 0.015 0.137 3.862 0.000
  MTHFR 677C>T allele 0.076 0.018 0.145 4.099 0.000
  SCARB1 rs5888 genotype −0.062 0.018 −0.122 −3.523 0.000
ApoB ABCA-1 V825I genotype 0.023 0.011 0.074 2.041 0.042
  ABCA-1 V825I allele 0.046 0.017 0.096 2.652 0.008
  LIPC -250G>A genotype −0.034 0.012 −0.101 −2.777 0.006
  MTHFR 677C>T genotype 0.028 0.013 0.077 2.147 0.032
  MTHFR 677C>T allele 0.048 0.016 0.107 2.992 0.003
  MYLIP rs3757354 genotype −0.026 0.012 −0.079 −2.190 0.029
  SCARB1 rs5888 allele −0.052 0.015 −0.129 −3.587 0.000
ApoA1/ApoB ABCA-1 V825I genotype −0.093 0.029 −0.114 −3.168 0.002
  ABCA-1 V825I allele −0.185 0.044 −0.149 −4.172 0.000
  LIPC -250G>A genotype 0.132 0.036 0.132 3.698 0.000
  LIPC -250G>A allele 0.114 0.048 0.085 2.361 0.018
  MYLIP rs3757354 genotype 0.058 0.030 0.071 1.965 0.050
  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.