Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Yin, Rui-Xing; Wu, Dong-Feng; Miao, Lin; Aung, Lynn Htet Htet; Cao, Xiao-Li; Yan, Ting-Ting; Long, Xing-Jiang; Liu, Wan-Ying; Zhang, Lin; Li, Meng

doi:10.1186/1475-2840-11-123

Cardiovascular Diabetology

Table 7 Correlation between genotypes or alleles and serum lipid levels in the overweight/obese subjects

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid	Genotype/allele	Unstandardized coefficient	Std. cp error	Standardized coefficient	t	P
TC	ABCA-1 V825I all`ele	0.162	0.078	0.074	2.078	0.038
	LIPG 584C>T genotype	0.228	0.073	0.109	3.122	0.002
	LIPG 584C>T allele	0.251	0.084	0.105	2.993	0.003
	MTHFR 677C>T genotype	0.158	0.060	0.092	2.624	0.009
	MTHFR 677C>T allele	0.245	0.075	0.115	3.267	0.001
	MYLIP rs3757354 genotype	−0.121	0.054	−0.082	−2.264	0.024
	PPARD +294T>C allele	0.222	0.083	0.096	2.666	0.008
	SCARB1 rs5888 allele	−0.182	0.069	−0.095	−2.633	0.009
TG	MTHFR 677C>T genotype	0.272	0.106	0.090	2.556	0.011
	PCSK9 E670G genotype	1.251	0.309	0.137	4.053	0.000
	PPARD +294T>C allele	0.675	0.179	0.133	3.763	0.000
	SCARB1 rs5888 genotype	0.232	0.099	0.084	2.337	0.020
HDL-C	ABCA-1 V825I genotype	−0.048	0.022	−0.077	−2.193	0.029
	LIPG 584C>T genotype	0.087	0.026	0.114	3.337	0.001
	LIPG 584C>T allele	0.068	0.030	0.078	2.270	0.024
	MTHFR 677C>T genotype	0.097	0.023	0.146	4.122	0.000
	MTHFR 677C>T allele	0.138	0.029	0.167	4.721	0.000
	PCSK9 E670G genotype	−0.167	0.075	−0.076	−2.234	0.026
	SCARB1 rs5888 genotype	−0.069	0.029	−0.084	−2.265	0.018
LDL-C	ABCA-1 V825I genotype	0.134	0.040	0.119	3.308	0.001
	ABCA-1 V825I allele	0.228	0.061	0.134	3.726	0.000
	LIPG 584C>T genotype	0.115	0.054	0.076	2.106	0.035
	LIPG 584C>T allele	0.131	0.062	0.077	2.116	0.035
ApoA1	ABCA-1 V825I allele	−0.044	0.020	−0.075	−2.138	0.033
	LIPG 584C>T genotype	0.036	0.018	0.071	2.038	0.042
	MTHFR 677C>T genotype	0.057	0.015	0.137	3.862	0.000
	MTHFR 677C>T allele	0.076	0.018	0.145	4.099	0.000
	SCARB1 rs5888 genotype	−0.062	0.018	−0.122	−3.523	0.000
ApoB	ABCA-1 V825I genotype	0.023	0.011	0.074	2.041	0.042
	ABCA-1 V825I allele	0.046	0.017	0.096	2.652	0.008
	LIPC -250G>A genotype	−0.034	0.012	−0.101	−2.777	0.006
	MTHFR 677C>T genotype	0.028	0.013	0.077	2.147	0.032
	MTHFR 677C>T allele	0.048	0.016	0.107	2.992	0.003
	MYLIP rs3757354 genotype	−0.026	0.012	−0.079	−2.190	0.029
	SCARB1 rs5888 allele	−0.052	0.015	−0.129	−3.587	0.000
ApoA1/ApoB	ABCA-1 V825I genotype	−0.093	0.029	−0.114	−3.168	0.002
	ABCA-1 V825I allele	−0.185	0.044	−0.149	−4.172	0.000
	LIPC -250G>A genotype	0.132	0.036	0.132	3.698	0.000
	LIPC -250G>A allele	0.114	0.048	0.085	2.361	0.018
	MYLIP rs3757354 genotype	0.058	0.030	0.071	1.965	0.050

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.

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ISSN: 1475-2840

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