Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Yin, Rui-Xing; Wu, Dong-Feng; Miao, Lin; Aung, Lynn Htet Htet; Cao, Xiao-Li; Yan, Ting-Ting; Long, Xing-Jiang; Liu, Wan-Ying; Zhang, Lin; Li, Meng

doi:10.1186/1475-2840-11-123

Cardiovascular Diabetology

Table 6 Correlation between genotypes or alleles and serum lipid levels in the normal weight subjects

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid	Genotype/allele	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
TC	ACAT-1 rs1044925 genotype	−0.131	0.053	−0.078	−2.477	0.013
	LDL-R Ava II genotype	−0.089	0.043	−0.062	−2.049	0.041
	LDL-R Ava II allele	−0.121	0.056	−0.066	−2.178	0.030
	LIPC -250G>A genotype	0.156	0.045	0.106	3.443	0.001
	LIPC -250G>A allele	0.204	0.057	0.111	3.593	0.000
	MTHFR 677C>T genotype	0.266	0.046	0.179	5.768	0.000
	MTHFR 677C>T allele	0.290	0.057	0.158	5.089	0.000
	PPARD +294T>C genotype	0.101	0.048	0.066	2.104	0.036
TG	LIPC -250G>A allele	0.149	0.065	0.072	2.292	0.022
	MYLIP rs3757354 genotype	−0.101	0.045	−0.071	−2.251	0.025
	SCARB1 rs5888 genotype	−0.142	0.066	−0.068	−2.157	0.031
HDL-C	ACAT-1 rs1044925 genotype	−0.061	0.028	−0.068	−2.177	0.030
	LIPC -250G>A genotype	0.045	0.022	0.062	2.040	0.042
	LIPG 584C>T genotype	0.085	0.025	0.104	3.364	0.001
	LIPG 584C>T allele	0.085	0.030	0.089	2.877	0.004
	MTHFR 677C>T genotype	0.105	0.024	0.134	4.361	0.000
	MTHFR 677C>T allele	0.129	0.030	0.134	4.352	0.000
	MYLIP rs3757354 genotype	0.054	0.021	0.082	2.609	0.009
LDL-C	LIPC -250G>A genotype	0.080	0.037	0.067	2.171	0.030
	LIPC -250G>A allele	0.125	0.046	0.084	2.713	0.007
	MTHFR 677C>T genotype	0.146	0.036	0.126	4.016	0.000
	MTHFR 677C>T allele	0.156	0.045	0.109	3.493	0.000
ApoA1	ACAT-1 rs1044925 genotype	−0.047	0.018	−0.080	−2.606	0.009
	LIPC -250G>A genotype	0.048	0.016	0.087	2.969	0.003
	LIPC -250G>A allele	0.051	0.020	0.074	2.516	0.012
	LIPG 584C>T genotype	0.040	0.016	0.075	2.467	0.014
	LIPG 584C>T allele	0.049	0.019	0.079	2.608	0.009
	MTHFR 677C>T genotype	0.057	0.014	0.121	3.965	0.000
	MTHFR 677C>T allele	0.071	0.018	0.122	4.019	0.000
	SCARB1 rs5888 genotype	−0.034	0.012	−0.065	−2.742	0.006
ApoB	LIPC -250G>A allele	0.033	0.013	0.078	2.498	0.013
	MTHFR 677C>T genotype	0.037	0.011	0.105	3.359	0.001
	MTHFR 677C>T allele	0.039	0.013	0.091	2.904	0.004
	SCARB1 rs5888 allele	−0.012	0.010	−0.048	−2.043	0.041

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.

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ISSN: 1475-2840

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