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Table 6 Correlation between genotypes or alleles and serum lipid levels in the normal weight subjects

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid Genotype/allele Unstandardized coefficient Std. error Standardized coefficient t P
TC ACAT-1 rs1044925 genotype −0.131 0.053 −0.078 −2.477 0.013
  LDL-R Ava II genotype −0.089 0.043 −0.062 −2.049 0.041
  LDL-R Ava II allele −0.121 0.056 −0.066 −2.178 0.030
  LIPC -250G>A genotype 0.156 0.045 0.106 3.443 0.001
  LIPC -250G>A allele 0.204 0.057 0.111 3.593 0.000
  MTHFR 677C>T genotype 0.266 0.046 0.179 5.768 0.000
  MTHFR 677C>T allele 0.290 0.057 0.158 5.089 0.000
  PPARD +294T>C genotype 0.101 0.048 0.066 2.104 0.036
TG LIPC -250G>A allele 0.149 0.065 0.072 2.292 0.022
  MYLIP rs3757354 genotype −0.101 0.045 −0.071 −2.251 0.025
  SCARB1 rs5888 genotype −0.142 0.066 −0.068 −2.157 0.031
HDL-C ACAT-1 rs1044925 genotype −0.061 0.028 −0.068 −2.177 0.030
  LIPC -250G>A genotype 0.045 0.022 0.062 2.040 0.042
  LIPG 584C>T genotype 0.085 0.025 0.104 3.364 0.001
  LIPG 584C>T allele 0.085 0.030 0.089 2.877 0.004
  MTHFR 677C>T genotype 0.105 0.024 0.134 4.361 0.000
  MTHFR 677C>T allele 0.129 0.030 0.134 4.352 0.000
  MYLIP rs3757354 genotype 0.054 0.021 0.082 2.609 0.009
LDL-C LIPC -250G>A genotype 0.080 0.037 0.067 2.171 0.030
  LIPC -250G>A allele 0.125 0.046 0.084 2.713 0.007
  MTHFR 677C>T genotype 0.146 0.036 0.126 4.016 0.000
  MTHFR 677C>T allele 0.156 0.045 0.109 3.493 0.000
ApoA1 ACAT-1 rs1044925 genotype −0.047 0.018 −0.080 −2.606 0.009
  LIPC -250G>A genotype 0.048 0.016 0.087 2.969 0.003
  LIPC -250G>A allele 0.051 0.020 0.074 2.516 0.012
  LIPG 584C>T genotype 0.040 0.016 0.075 2.467 0.014
  LIPG 584C>T allele 0.049 0.019 0.079 2.608 0.009
  MTHFR 677C>T genotype 0.057 0.014 0.121 3.965 0.000
  MTHFR 677C>T allele 0.071 0.018 0.122 4.019 0.000
  SCARB1 rs5888 genotype −0.034 0.012 −0.065 −2.742 0.006
ApoB LIPC -250G>A allele 0.033 0.013 0.078 2.498 0.013
  MTHFR 677C>T genotype 0.037 0.011 0.105 3.359 0.001
  MTHFR 677C>T allele 0.039 0.013 0.091 2.904 0.004
  SCARB1 rs5888 allele −0.012 0.010 −0.048 −2.043 0.041
  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.