Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Yin, Rui-Xing; Wu, Dong-Feng; Miao, Lin; Aung, Lynn Htet Htet; Cao, Xiao-Li; Yan, Ting-Ting; Long, Xing-Jiang; Liu, Wan-Ying; Zhang, Lin; Li, Meng

doi:10.1186/1475-2840-11-123

Cardiovascular Diabetology

Table 5 Correlation between genotypes or alleles and serum lipid levels in the total population

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid	Genotype/allele	Unstandardized coefficient	Std. error	Standardized coefficient	t	P
TC	ACAT-1 rs1044925 genotype	−0.099	0.043	−0.053	−2.287	0.022
	LIPC -250G>A allele	0.101	0.046	0.050	2.170	0.030
	LIPG 584C>T genotype	0.149	0.043	0.079	3.503	0.000
	LIPG 584C>T allele	0.169	0.049	0.077	3.425	0.001
	MTHFR 677C>T genotype	0.218	0.037	0.133	5.854	0.000
	MTHFR 677C>T allele	0.269	0.046	0.133	5.841	0.000
	PPARD +294T>C allele	0.147	0.050	0.068	2.963	0.003
TG	MTHFR 677C>T genotype	0.146	0.054	0.062	2.701	0.007
	MYLIP rs3757354 genotype	−0.102	0.042	−0.057	−2.456	0.014
	PPARD +294T>C allele	0.321	0.086	0.087	3.732	0.000
	SCARB1 rs5888 genotype	−0.041	0.023	−0.049	−2.039	0.042
HDL-C	ACAT-1 rs1044925 genotype	−0.057	0.022	−0.062	−2.643	0.008
	ACAT-1 rs1044925 allele	−0.051	0.025	−0.048	−2.024	0.043
	LIPC -250G>A genotype	0.038	0.016	0.055	2.366	0.018
	LIPG 584C>T genotype	0.086	0.018	0.108	4.667	0.000
	LIPG 584C>T allele	0.080	0.021	0.087	3.762	0.000
	MTHFR 677C>T genotype	0.097	0.017	0.132	5.718	0.000
	MTHFR 677C>T allele	0.123	0.021	0.136	5.868	0.000
	MYLIP rs3757354 genotype	0.036	0.015	0.058	2.465	0.014
LDL-C	ABCA-1 V825I genotype	0.075	0.025	0.068	2.954	0.003
	MTHFR 677C>T genotype	0.075	0.029	0.059	2.562	0.010
	MTHFR 677C>T allele	0.120	0.036	0.077	3.334	0.001
ApoA1	ACAT-1 rs1044925 genotype	−0.042	0.013	−0.074	−3.143	0.002
	ACAT-1 rs1044925 allele	−0.042	0.016	−0.063	−2.672	0.008
	LIPC -250G>A genotype	0.036	0.012	0.068	3.020	0.003
	LIPG 584C>T genotype	0.040	0.012	0.076	3.303	0.001
	LIPG 584C>T allele	0.039	0.014	0.064	2.781	0.005
	MTHFR 677C>T genotype	0.053	0.010	0.118	5.130	0.000
	MTHFR 677C>T allele	0.068	0.013	0.123	5.338	0.000
ApoB	MTHFR 677C>T genotype	0.032	0.008	0.086	3.781	0.000
	MTHFR 677C>T allele	0.042	0.010	0.092	4.049	0.000
ApoA1/ApoB	LIPC -250G>A genotype	0.070	0.026	0.063	2.649	0.008

TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.

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ISSN: 1475-2840

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