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Table 5 Correlation between genotypes or alleles and serum lipid levels in the total population

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

Lipid Genotype/allele Unstandardized coefficient Std. error Standardized coefficient t P
TC ACAT-1 rs1044925 genotype −0.099 0.043 −0.053 −2.287 0.022
  LIPC -250G>A allele 0.101 0.046 0.050 2.170 0.030
  LIPG 584C>T genotype 0.149 0.043 0.079 3.503 0.000
  LIPG 584C>T allele 0.169 0.049 0.077 3.425 0.001
  MTHFR 677C>T genotype 0.218 0.037 0.133 5.854 0.000
  MTHFR 677C>T allele 0.269 0.046 0.133 5.841 0.000
  PPARD +294T>C allele 0.147 0.050 0.068 2.963 0.003
TG MTHFR 677C>T genotype 0.146 0.054 0.062 2.701 0.007
  MYLIP rs3757354 genotype −0.102 0.042 −0.057 −2.456 0.014
  PPARD +294T>C allele 0.321 0.086 0.087 3.732 0.000
  SCARB1 rs5888 genotype −0.041 0.023 −0.049 −2.039 0.042
HDL-C ACAT-1 rs1044925 genotype −0.057 0.022 −0.062 −2.643 0.008
  ACAT-1 rs1044925 allele −0.051 0.025 −0.048 −2.024 0.043
  LIPC -250G>A genotype 0.038 0.016 0.055 2.366 0.018
  LIPG 584C>T genotype 0.086 0.018 0.108 4.667 0.000
  LIPG 584C>T allele 0.080 0.021 0.087 3.762 0.000
  MTHFR 677C>T genotype 0.097 0.017 0.132 5.718 0.000
  MTHFR 677C>T allele 0.123 0.021 0.136 5.868 0.000
  MYLIP rs3757354 genotype 0.036 0.015 0.058 2.465 0.014
LDL-C ABCA-1 V825I genotype 0.075 0.025 0.068 2.954 0.003
  MTHFR 677C>T genotype 0.075 0.029 0.059 2.562 0.010
  MTHFR 677C>T allele 0.120 0.036 0.077 3.334 0.001
ApoA1 ACAT-1 rs1044925 genotype −0.042 0.013 −0.074 −3.143 0.002
  ACAT-1 rs1044925 allele −0.042 0.016 −0.063 −2.672 0.008
  LIPC -250G>A genotype 0.036 0.012 0.068 3.020 0.003
  LIPG 584C>T genotype 0.040 0.012 0.076 3.303 0.001
  LIPG 584C>T allele 0.039 0.014 0.064 2.781 0.005
  MTHFR 677C>T genotype 0.053 0.010 0.118 5.130 0.000
  MTHFR 677C>T allele 0.068 0.013 0.123 5.338 0.000
ApoB MTHFR 677C>T genotype 0.032 0.008 0.086 3.781 0.000
  MTHFR 677C>T allele 0.042 0.010 0.092 4.049 0.000
ApoA1/ApoB LIPC -250G>A genotype 0.070 0.026 0.063 2.649 0.008
  1. TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.