Table 4 Interactions of several SNPs and overweight/obesity on serum lipid levels
From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels
SNP | Genotype | TC (mmol/L) | TG (mmol/L) | HDL-C (mmol/L) | LDL-C (mmol/L) | ApoA1 (g/L) | ApoB (g/L) | ApoA1/ ApoB |
|---|---|---|---|---|---|---|---|---|
ABCA-1 V825I | GG | – | – | – | – | – | – | – |
(rs2066715) | GA | – | – | – | ↑ | – | – | ↓ |
AA | – | – | – | ↑ | – | – | ↓ | |
F | 1.473 | 2.937 | 1.717 | 3.687 | 1.913 | 2.941 | 6.485 | |
P | 0.230 | 0.053 | 0.180 | 0.005c | 0.148 | 0.053 | 0.000c | |
ACAT-1 rs1044925 | AA | – | – | – | – | – | – | – |
(rs1044925) | AC | – | – | – | – | – | – | – |
CC | – | – | – | – | – | – | – | |
F | 0.475 | 1.457 | 0.341 | 0.320 | 1.635 | 1.071 | 1.944 | |
P | 0.622 | 0.233 | 0.711 | 0.726 | 0.195 | 0.343 | 0.143 | |
LDL-R Ava II | A-A- | – | – | – | – | – | – | – |
A-A+ | – | – | – | – | – | – | – | |
A+A+ | – | – | – | – | – | – | – | |
F | 1.681 | 0.242 | 0.553 | 0.857 | 1.377 | 0.430 | 0.462 | |
P | 0.186 | 0.785 | 0.576 | 0.425 | 0.253 | 0.650 | 0.630 | |
LIPC -250G>A | GG | ↑ | – | – | ↑ | – | ↑ | – |
(rs2070895) | GA | – | – | – | – | – | ↑ | – |
AA | – | – | – | – | ↑ | – | – | |
F | 3.733 | 0.266 | 1.584 | 3.345 | 3.292 | 4.138 | 2.116 | |
P | 0.005c | 0.766 | 0.205 | 0.007c | 0.007c | 0.003c | 0.121 | |
LIPG 584C>T | CC | – | – | – | – | – | – | – |
(rs2000813) | CT | – | – | – | – | – | – | – |
TT | – | – | – | – | – | ↑ | – | |
F | 1.286 | 0.210 | 0.357 | 1.452 | 2.195 | 3.616 | 1.812 | |
P | 0.277 | 0.810 | 0.700 | 0.234 | 0.112 | 0.005c | 0.164 | |
MTHFR 677C>T | CC | – | – | – | ↑ | – | – | – |
(rs1801133) | CT | ↑ | – | – | – | – | – | – |
TT | – | ↑ | – | ↓ | – | – | – | |
F | 3.110 | 3.463 | 0.627 | 9.236 | 0.058 | 2.684 | 0.675 | |
P | 0.009c | 0.006c | 0.534 | 0.000c | 0.944 | 0.069 | 0.509 | |
MYLIP | AA | – | – | – | – | – | – | – |
(rs3757354) | AG | ↑ | ↑ | – | – | – | – | – |
GG | – | – | – | – | – | – | – | |
F | 6.864 | 4.325 | 1.818 | 2.495 | 0.684 | 1.895 | 1.388 | |
P | 0.000c | 0.003c | 0.307 | 0.083 | 0.505 | 0.151 | 0.250 | |
PCSK9 E670G | AA | – | – | – | – | – | – | – |
(rs505151) | AG | – | ↑ | ↓ | – | – | ↑ | ↓ |
F | 0.980 | 25.662 | 7.831 | 0.002 | 1.371 | 6.319 | 4.357 | |
P | 0.322 | 0.000c | 0.001c | 0.968 | 0.242 | 0.002c | 0.007c | |
PPARD +294T>C | TT | – | – | – | – | – | – | – |
(rs2016520) | TC | – | ↑ | – | – | – | – | – |
CC | – | – | – | – | – | – | ↑ | |
F | 1.832 | 5.737 | 1.235 | 1.087 | 0.171 | 1.362 | 3.985 | |
P | 0.160 | 0.001c | 0.291 | 0.337 | 0.843 | 0.257 | 0.004c | |
SCARB1 | CC | – | – | – | – | – | ↑ | – |
(rs5888) | CT | – | – | – | – | ↓ | – | – |
TT | – | ↑ | – | – | ↓ | – | – | |
F | 1.809 | 4.396 | 1.720 | 2.211 | 3.226 | 3.118 | 0.051 | |
P | 0.164 | 0.002c | 0.179 | 0.110 | 0.008c | 0.009c | 0.778 |