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Table 4 Interactions of several SNPs and overweight/obesity on serum lipid levels

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

SNP Genotype TC (mmol/L) TG (mmol/L) HDL-C (mmol/L) LDL-C (mmol/L) ApoA1 (g/L) ApoB (g/L) ApoA1/ ApoB
ABCA-1 V825I GG
(rs2066715) GA
  AA
  F 1.473 2.937 1.717 3.687 1.913 2.941 6.485
  P 0.230 0.053 0.180 0.005c 0.148 0.053 0.000c
ACAT-1 rs1044925 AA
(rs1044925) AC
  CC
  F 0.475 1.457 0.341 0.320 1.635 1.071 1.944
  P 0.622 0.233 0.711 0.726 0.195 0.343 0.143
LDL-R Ava II A-A-
  A-A+
  A+A+
  F 1.681 0.242 0.553 0.857 1.377 0.430 0.462
  P 0.186 0.785 0.576 0.425 0.253 0.650 0.630
LIPC -250G>A GG
(rs2070895) GA
  AA
  F 3.733 0.266 1.584 3.345 3.292 4.138 2.116
  P 0.005c 0.766 0.205 0.007c 0.007c 0.003c 0.121
LIPG 584C>T CC
(rs2000813) CT
  TT
  F 1.286 0.210 0.357 1.452 2.195 3.616 1.812
  P 0.277 0.810 0.700 0.234 0.112 0.005c 0.164
MTHFR 677C>T CC
(rs1801133) CT
  TT
  F 3.110 3.463 0.627 9.236 0.058 2.684 0.675
  P 0.009c 0.006c 0.534 0.000c 0.944 0.069 0.509
MYLIP AA
(rs3757354) AG
  GG
  F 6.864 4.325 1.818 2.495 0.684 1.895 1.388
  P 0.000c 0.003c 0.307 0.083 0.505 0.151 0.250
PCSK9 E670G AA
(rs505151) AG
  F 0.980 25.662 7.831 0.002 1.371 6.319 4.357
  P 0.322 0.000c 0.001c 0.968 0.242 0.002c 0.007c
PPARD +294T>C TT
(rs2016520) TC
  CC
  F 1.832 5.737 1.235 1.087 0.171 1.362 3.985
  P 0.160 0.001c 0.291 0.337 0.843 0.257 0.004c
SCARB1 CC
(rs5888) CT
  TT
  F 1.809 4.396 1.720 2.211 3.226 3.118 0.051
  P 0.164 0.002c 0.179 0.110 0.008c 0.009c 0.778
  1. SNP, single nucleotide polymorphism; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; ApoA1, apolipoprotein A1; ApoB, apolipoprotein B; ApoA1/ApoB, the ratio of apolipoprotein A1 to apolipoprotein B; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1; “C” is the P- value after permutation correction. ↑: genotype and overweight/obesity interactions to increase serum lipid levels; ↓: genotype and overweight/obesity interactions to decrease serum lipid levels; –: no interaction of genotypes and overweight/obesity on serum lipid levels.