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Table 3 The genotypic and allelic frequencies between the subjects with normal weight and overweight/obesity [n (%)]

From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels

SNP Genotype (Allele) Normal weight (n = 978) Overweight/obesity (n = 751) χ2 P
ABCA-1 V825I GG 326 (33.3) 269 (35.8)   
(rs2066715) GA 480 (49.1) 334 (44.5)   
  AA 172 (17.6) 148 (19.7) 3.708 0.157
  G 1132 (57.9) 872 (58.1)   
  A 824 (42.1) 630 (41.9) 0.012 0.914
ACAT-1 AA 662 (67.7) 527 (70.2)   
(rs1044925) AC 279 (28.5) 205 (27.3)   
  CC 37 (3.8) 19 (2.5) 2.671 0.263
  A 1603 (82.0) 1259 (83.8)   
  C 353 (18.0) 243 (16.2) 2.080 0.149
LDL-R Ava II A-A- 527 (53.9) 389 (51.8)   
  A-A+ 371 (37.9) 295 (39.3)   
  A+A+ 80 (8.2) 67 (8.9) 0.824 0.662
  A- 1425 (72.9) 1073 (71.4)   
  A+ 531 (27.1) 429 (28.6) 0.848 0.357
LIPC -250G>A GG 480 (49.1) 233 (31.0)   
(rs2070895) GA 425 (43.5) 432 (57.5)   
  AA 73 (7.5) 86 (11.5) 57.882 0.000
  G 1385 (70.8) 898 (59.8)   
  A 571 (29.2) 604 (40.2) 45.999 0.000
LIPG 584C>T CC 454 (46.4) 308 (41.0)   
(rs2000813) CT 477 (48.8) 412 (54.9)   
  TT 47 (4.8) 31 (4.1) 6.314 0.043
  C 1385 (70.8) 1028 (68.4)   
  T 571 (29.2) 474 (31.6) 2.255 0.133
MTHFR 677C>T CC 471 (48.2) 354 (47.1)   
(rs1801133) CT 441 (45.1) 341 (45.4)   
  TT 66 (6.7) 56 (7.5) 0.404 0.817
  C 1383 (70.7) 1049 (69.8)   
  T 573 (29.3) 453 (30.2) 0.305 0.581
MYLIP AA 230 (23.5) 148 (19.7)   
(rs3757354) AG 477 (48.8) 363 (48.3)   
  GG 271 (27.7) 240 (32.0) 5.431 0.066
  A 937 (47.9) 659 (43.9)   
  G 1019 (52.1) 843 (56.1) 5.550 0.018
PCSK9 E670G AA 916 (93.7) 721 (96.0)   
(rs505151) AG 62 (6.3) 30 (4.0)   
  GG 0 0 4.636 0.031
  A 1894 (96.8) 1472 (98.0)   
  G 62 (3.2) 30 (2.0) 4.509 0.034
PPARD +294T>C TT 559 (57.2) 396 (52.7)   
(rs2016520) TC 354 (36.2) 312 (41.5)   
  CC 65 (6.6) 43 (5.7) 5.239 0.073
  T 1472 (75.3) 1104 (73.5)   
  C 484 (24.7) 398 (26.5) 1.375 0.241
SCARB1 CC 548 (56.0) 417 (55.5)   
(rs5888) CT 390 (39.9) 311 (41.4)   
  TT 40 (4.1) 23 (3.1) 1.497 0.473
  C 1486 (76.0) 1145 (76.2)   
  T 470 (24.0) 357 (23.8) 0.032 0.859
  1. SNP, single nucleotide polymorphism; ABCA-1, ATP-binding cassette transporter A1; ACAT-1, acyl-CoA:cholesterol acyltransferase-1; LDL-R, low density lipoprotein receptor; LIPC, hepatic lipase gene; LIPG, endothelial lipase gene; MTHFR, methylenetetrahydrofolate reductase; MYLIP, the E3 ubiquitin ligase myosin regulatory light chain-interacting protein; PCSK9, proprotein convertase subtilisin-like kexin type 9; PPARD, peroxisome proliferator-activated receptor delta; SCARB1, Scavenger receptor class B type 1.