Table 3 The genotypic and allelic frequencies between the subjects with normal weight and overweight/obesity [n (%)]
From: Several genetic polymorphisms interact with overweight/obesity to influence serum lipid levels
SNP | Genotype (Allele) | Normal weight (n = 978) | Overweight/obesity (n = 751) | χ2 | P |
|---|---|---|---|---|---|
ABCA-1 V825I | GG | 326 (33.3) | 269 (35.8) | Â | Â |
(rs2066715) | GA | 480 (49.1) | 334 (44.5) | Â | Â |
| Â | AA | 172 (17.6) | 148 (19.7) | 3.708 | 0.157 |
| Â | G | 1132 (57.9) | 872 (58.1) | Â | Â |
| Â | A | 824 (42.1) | 630 (41.9) | 0.012 | 0.914 |
ACAT-1 | AA | 662 (67.7) | 527 (70.2) | Â | Â |
(rs1044925) | AC | 279 (28.5) | 205 (27.3) | Â | Â |
| Â | CC | 37 (3.8) | 19 (2.5) | 2.671 | 0.263 |
| Â | A | 1603 (82.0) | 1259 (83.8) | Â | Â |
| Â | C | 353 (18.0) | 243 (16.2) | 2.080 | 0.149 |
LDL-R Ava II | A-A- | 527 (53.9) | 389 (51.8) | Â | Â |
| Â | A-A+ | 371 (37.9) | 295 (39.3) | Â | Â |
| Â | A+A+ | 80 (8.2) | 67 (8.9) | 0.824 | 0.662 |
| Â | A- | 1425 (72.9) | 1073 (71.4) | Â | Â |
| Â | A+ | 531 (27.1) | 429 (28.6) | 0.848 | 0.357 |
LIPC -250G>A | GG | 480 (49.1) | 233 (31.0) | Â | Â |
(rs2070895) | GA | 425 (43.5) | 432 (57.5) | Â | Â |
| Â | AA | 73 (7.5) | 86 (11.5) | 57.882 | 0.000 |
| Â | G | 1385 (70.8) | 898 (59.8) | Â | Â |
| Â | A | 571 (29.2) | 604 (40.2) | 45.999 | 0.000 |
LIPG 584C>T | CC | 454 (46.4) | 308 (41.0) | Â | Â |
(rs2000813) | CT | 477 (48.8) | 412 (54.9) | Â | Â |
| Â | TT | 47 (4.8) | 31 (4.1) | 6.314 | 0.043 |
| Â | C | 1385 (70.8) | 1028 (68.4) | Â | Â |
| Â | T | 571 (29.2) | 474 (31.6) | 2.255 | 0.133 |
MTHFR 677C>T | CC | 471 (48.2) | 354 (47.1) | Â | Â |
(rs1801133) | CT | 441 (45.1) | 341 (45.4) | Â | Â |
| Â | TT | 66 (6.7) | 56 (7.5) | 0.404 | 0.817 |
| Â | C | 1383 (70.7) | 1049 (69.8) | Â | Â |
| Â | T | 573 (29.3) | 453 (30.2) | 0.305 | 0.581 |
MYLIP | AA | 230 (23.5) | 148 (19.7) | Â | Â |
(rs3757354) | AG | 477 (48.8) | 363 (48.3) | Â | Â |
| Â | GG | 271 (27.7) | 240 (32.0) | 5.431 | 0.066 |
| Â | A | 937 (47.9) | 659 (43.9) | Â | Â |
| Â | G | 1019 (52.1) | 843 (56.1) | 5.550 | 0.018 |
PCSK9 E670G | AA | 916 (93.7) | 721 (96.0) | Â | Â |
(rs505151) | AG | 62 (6.3) | 30 (4.0) | Â | Â |
| Â | GG | 0 | 0 | 4.636 | 0.031 |
| Â | A | 1894 (96.8) | 1472 (98.0) | Â | Â |
| Â | G | 62 (3.2) | 30 (2.0) | 4.509 | 0.034 |
PPARD +294T>C | TT | 559 (57.2) | 396 (52.7) | Â | Â |
(rs2016520) | TC | 354 (36.2) | 312 (41.5) | Â | Â |
| Â | CC | 65 (6.6) | 43 (5.7) | 5.239 | 0.073 |
| Â | T | 1472 (75.3) | 1104 (73.5) | Â | Â |
| Â | C | 484 (24.7) | 398 (26.5) | 1.375 | 0.241 |
SCARB1 | CC | 548 (56.0) | 417 (55.5) | Â | Â |
(rs5888) | CT | 390 (39.9) | 311 (41.4) | Â | Â |
| Â | TT | 40 (4.1) | 23 (3.1) | 1.497 | 0.473 |
| Â | C | 1486 (76.0) | 1145 (76.2) | Â | Â |
| Â | T | 470 (24.0) | 357 (23.8) | 0.032 | 0.859 |