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Table 1 Patient characteristics, laboratory values at baseline and co-morbid disease conditions

From: Oral antidiabetic treatment in type-2 diabetes in the elderly: balancing the need for glucose control and the risk of hypoglycemia

  Age ≥ 70 years Age < 70 to ≥ 60 years Age < 60 years p-value*
(n=1,373) (n=1,184) (n=1,253)
Median (IQR) or % Median (IQR) or % Median (IQR) or %
Age (years) 74.0 (72.0-78.0) 65.0 (62.0-67.0) 54.0 (49.0-57.0) <0.0001
Women (%) 51.1 45.9 42.5 <0.0001
Diabetes duration (years) 6.8 (3.9-10.6) 6.0 (3.3-9.5) 4.1 (1.9-7.3) <0.0001
Physically active (any sport) 31.0 42.9 47.8 <0.0001
Body Mass Index (kg/m2) 29.0 (26.0-33.0) 31.0 (28.0-35.0) 32.0 (28.0-36.0) <0.0001
 Men (kg/m2) 29.0 (26.0-32.0) 30.0 (27.0-33.0) 31.0 (28.0-36.0) <0.0001
 Women (kg/m2) 30.0 (27.0-34.0) 32.0 (28.0-36.0) 33.0 (29.0-38.0) <0.0001
Waist circumference (cm) 104 (96.0-113.0) 108 (98–117) 109 (99.0-120.0) <0.0001
HbA1c (%) 7.3 (6.8-7.9) 7.5 (6.9-8.4) 7.6 (6.9-8.9) <0.0001
Fasting plasma glucose (mmol/l) 7.7 (6.4-9.2) 7.8 (6.7-9.4) 8.1 (6.8-10.1) <0.0001
Postprandial plasma glucose (mmol/l) 10.0 (8.6-11.8) 10.2 (8.4-12.2) 10.5 (8.7-13.0) <0.0001
Co-morbidity     
 Dyslipidemia 64.9 65.5 59.3 <0.01
 Hypertension 90.5 86.2 76.0 <0.0001
 Coronary heart disease 28.1 16.0 8.5 <0.0001
  Myocardial infarction 28.8 37.0 50.0 <0.0001
  Stable angina 33.6 26.2 20.0 <0.01
  Unstable angina 3.2 3.8 5.1 0.40
  PCI 35.2 44.1 52.5 <0.001
  Bypass surgery 21.6 21.4 19.8 0.74
 Prior stroke / TIA 6.8 4.3 2.5 <0.0001
 Heart failure 18.6 7.5 2.6 <0.0001
 Peripheral arterial disease 8.2 6.4 3.2 <0.0001
 Amputation 1.3 0.6 0.8 0.16
 Autonomous neuropathy 4.4 3.5 2.1 <0.01
 Peripheral neuropathy 18.4 15.8 8.5 <0.0001
 NPDR 5.2 3.5 2.4 <0.001
 Proliferative retinopathy 1.0 0.4 0.1 <0.01
  1. Legend: HbA1c, glycosylated hemoglobin A1c; PCI, percutaneous coronary intervention; TIA, transitory ischemic attack; NPDR, non-proliferative retinopathy; * Cochran-Armitage or Jonchkheere-Terpstra test.