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Table 6 Association between ALT/AST ratio and insulin resistance (HOMA-IR ≥2.5) and HOMA-IR within selected subgroups

From: Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Stratified subgroups

N

HOMA-IR ≥2.5,%

ALT/AST ratio

   

ROC curves AUC (95%CI)

BMI-adjusted β (P-value)

Multivariate-adjusted β (P-value)

Men Body mass index (kg/m2)

     

 Total

587

66 (11.2)

0.75 (0.68-0.81

0.253 (<0.001)

0.104 (0.016)

  <22.0

202

7 (3.5)

0.67 (0.44-0.89)

0.257 (<0.001)

0.141 (0.051)

  22.0-25.0

225

19 (8.4)

0.64 (0.51-0.77)

0.317 (<0.001)

0.166 (0.030)

  <25.0

427

26 (6.1)

0.67 (0.56-0.77)

0.274 (<0.001)

0.143 (0.004)

  ≥25.0

160

40 (25.0)

0.73 (0.63-0.82)

0.215 (0.005)

0.052 (0.600)

Women Body mass index (kg/m2)

     

 Total

755

101 (13.4)

0.75 (0.70-0.81)

0.197 (<0.001)

0.104 (0.002)

  <22.0

308

10 (3.2)

0.74 (0.62-0.87)

0.149 (0.008)

0.055 (0.334)

  22.0-25.0

263

26 (9.9)

0.71 (0.60-0.82)

0.250 (<0.001)

0.136 (0.039)

  <25.0

571

36 (6.3)

0.74 (0.65-0.82)

0.194 (<0.001)

0.092 (0.026)

  ≥25.0

184

65 (35.3)

0.68 (0.60-0.76)

0.231 (0.001)

0.176 (0.019)

  1. Multivariate-adjusted for confounding factors in Table 4.