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Table 6 Association between ALT/AST ratio and insulin resistance (HOMA-IR ≥2.5) and HOMA-IR within selected subgroups

From: Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Stratified subgroups N HOMA-IR ≥2.5,% ALT/AST ratio
    ROC curves AUC (95%CI) BMI-adjusted β (P-value) Multivariate-adjusted β (P-value)
Men Body mass index (kg/m2)      
 Total 587 66 (11.2) 0.75 (0.68-0.81 0.253 (<0.001) 0.104 (0.016)
  <22.0 202 7 (3.5) 0.67 (0.44-0.89) 0.257 (<0.001) 0.141 (0.051)
  22.0-25.0 225 19 (8.4) 0.64 (0.51-0.77) 0.317 (<0.001) 0.166 (0.030)
  <25.0 427 26 (6.1) 0.67 (0.56-0.77) 0.274 (<0.001) 0.143 (0.004)
  ≥25.0 160 40 (25.0) 0.73 (0.63-0.82) 0.215 (0.005) 0.052 (0.600)
Women Body mass index (kg/m2)      
 Total 755 101 (13.4) 0.75 (0.70-0.81) 0.197 (<0.001) 0.104 (0.002)
  <22.0 308 10 (3.2) 0.74 (0.62-0.87) 0.149 (0.008) 0.055 (0.334)
  22.0-25.0 263 26 (9.9) 0.71 (0.60-0.82) 0.250 (<0.001) 0.136 (0.039)
  <25.0 571 36 (6.3) 0.74 (0.65-0.82) 0.194 (<0.001) 0.092 (0.026)
  ≥25.0 184 65 (35.3) 0.68 (0.60-0.76) 0.231 (0.001) 0.176 (0.019)
  1. Multivariate-adjusted for confounding factors in Table 4.