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Table 4 Multiple linear regression analysis of the correlation between various confounding factors and HOMA-IR of subjects categorized by body mass index

From: Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Body mass index† characteristics

β(P-value)

 

Total

Non-obese

Overweight

 

All N = 1,342

<25.0 kg/m2 N = 998

≥25.0 kg/m2 N = 344

Male sex,%

0.247 (<0.001)

0.281 (<0.001)

0.219 (0.005)

Age (years)

−0.064 (0.020)

−0.116 (0.001)

0.094 (0.135)

Body mass index (kg/m2)

0.320 (<0.001)

0.206 (<0.001)

0.262 (<0.001)

Smoking status {never/ex/light/heavy (%)}

−0.065 (0.014)

−0.060 (0.075)

−0.103 (0.073)

Alcohol consumption {never/light/moderate/heavy(%)}

−0.114 (<0.001)

−0.137 (<0.001)

−0.081 (0.222)

Cardiovascular disease,%

0.032 (0.140)

0.055 (0.046)

−0.024 (0.610)

Systolic blood pressure (mmHg)

0.093 (<0.001)

0.126 (<0.001)

0.032 (0.543)

Triglycerides (mg/dL)

0.138 (<0.001)

0.145 (<0.001)

0.164 (0.005)

HDL cholesterol (mg/dL)

−0.033 (0.215)

−0.038 (0.249)

−0.028 (0.645)

LDL cholesterol (mg/dL)

0.041 (0.079)

0.063 (0.034)

0.010 (0.848)

Uric acid (mg/dL)

0.021 (0.451)

0.049 (0.153)

−0.052 (0.400)

High sensitivity CRP (mg/dL)

0.049 (0.035)

0.048 (0.095)

0.074 (0.149)

Serum HMW adiponectin (μg/mL)

−0.164 (<0.001)

−0.162 (<0.001)

−0.231 (0.001)

GGT (IU/L)

0.097 (0.001)

0.079 (0.031)

0.149 (0.038)

ALT/AST ratio

0.122 (<0.001)

0.129 (<0.001)

0.143 (0.038)

R2

0.417 (<0.001)

0.315 (<0.001)

0.290 (<0.001)

  1. Data for triglycerides, high sensitivity CRP, serum HMW adiponectin, GGT, ALT/AST ratio and HOMA-IR were skewed and log-transformed for analysis.