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Table 4 Multiple linear regression analysis of the correlation between various confounding factors and HOMA-IR of subjects categorized by body mass index

From: Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Body mass index† characteristics β(P-value)
  Total Non-obese Overweight
  All N = 1,342 <25.0 kg/m2 N = 998 ≥25.0 kg/m2 N = 344
Male sex,% 0.247 (<0.001) 0.281 (<0.001) 0.219 (0.005)
Age (years) −0.064 (0.020) −0.116 (0.001) 0.094 (0.135)
Body mass index (kg/m2) 0.320 (<0.001) 0.206 (<0.001) 0.262 (<0.001)
Smoking status {never/ex/light/heavy (%)} −0.065 (0.014) −0.060 (0.075) −0.103 (0.073)
Alcohol consumption {never/light/moderate/heavy(%)} −0.114 (<0.001) −0.137 (<0.001) −0.081 (0.222)
Cardiovascular disease,% 0.032 (0.140) 0.055 (0.046) −0.024 (0.610)
Systolic blood pressure (mmHg) 0.093 (<0.001) 0.126 (<0.001) 0.032 (0.543)
Triglycerides (mg/dL) 0.138 (<0.001) 0.145 (<0.001) 0.164 (0.005)
HDL cholesterol (mg/dL) −0.033 (0.215) −0.038 (0.249) −0.028 (0.645)
LDL cholesterol (mg/dL) 0.041 (0.079) 0.063 (0.034) 0.010 (0.848)
Uric acid (mg/dL) 0.021 (0.451) 0.049 (0.153) −0.052 (0.400)
High sensitivity CRP (mg/dL) 0.049 (0.035) 0.048 (0.095) 0.074 (0.149)
Serum HMW adiponectin (μg/mL) −0.164 (<0.001) −0.162 (<0.001) −0.231 (0.001)
GGT (IU/L) 0.097 (0.001) 0.079 (0.031) 0.149 (0.038)
ALT/AST ratio 0.122 (<0.001) 0.129 (<0.001) 0.143 (0.038)
R2 0.417 (<0.001) 0.315 (<0.001) 0.290 (<0.001)
  1. Data for triglycerides, high sensitivity CRP, serum HMW adiponectin, GGT, ALT/AST ratio and HOMA-IR were skewed and log-transformed for analysis.