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Table 3 Comparison of areas under the ROC curves (95% CI) for potential markers of insulin resistance (HOMA-IR ≥2.5) of subjects categorized by body mass index

From: Alanine aminotransferase/aspartate aminotransferase ratio is the best surrogate marker for insulin resistance in non-obese Japanese adults

Body mass index characteristics AUC (95% CI)
  Total P-value Non-obese P-value Overweight P-value
  All N = 1,342   <25.0 kg/m2 N = 998   ≥25.0 kg/m2 N = 344  
Triglycerides (mg/dL) 0.69 (0.65-0.73) <0.001 0.66 (0.59-0.73) <0.001 0.65 (0.58-0.71) <0.001
High sensitivity CRP (mg/dL) 0.68 (0.64-0.72) <0.001 0.61 (0.55-0.68) 0.003 0.63 (0.57-0.70) <0.001
Serum HMW adiponectin (μg/mL) 0.32 (0.28-0.36) <0.001 0.32 (0.25-0.39) <0.001 0.40 (0.33-0.46) 0.003
GGT (IU/L) 0.63 (0.58-0.67) <0.001 0.61 (0.54-0.67) 0.005 0.54 (0.48-0.61) 0.211
ALT (IU/L) 0.69 (0.64-0.73) <0.001 0.62 (0.55-0.69) 0.002 0.66 (0.59-0.72) <0.001
AST (IU/L) 0.56 (0.51-0.61) 0.013 0.49 (0.41-0.57) 0.818 0.59 (0.52-0.66) 0.007
ALT/AST ratio 0.74 (0.70-0.78) <0.001 0.70 (0.63-0.77) <0.001 0.66 (0.59-0.72) <0.001
  1. ROC, receiver operating characteristics; CI, confidence interval; AUC, area under ROC curve. Data for triglycerides, high sensitivity CRP, serum HMW adiponectin, GGT, ALT, AST, and ALT/AST ratio were skewed and log-transformed for analysis.