Table 3 Fatty acid composition of serum, EAT, MAT and SAT of obese CAD group (n = 15) and controls (n = 5)
In SERUM | In EAT | In MAT | In SAT | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Fatty acids | Obese CAD group (n = 15) | Controls (n = 5) | P value | Obese CAD group (n = 15) | Controls (n = 5) | P value | Obese CAD group (n = 15) | Controls (n = 5) | P value | Obese CAD group (n = 15) | Controls (n = 5) | P value |
14:0 (myristic acid) | 32.7 ± 4.8 | 32.3 ± 7.9 | NS | 9.6 ± 0.8 | 11.9 ± 1.1 | NS | 10 ± 0.9 | 9.7 ± 1.4 | NS | 10.1 ± 0.7 | 10.4 ± 0.7 | NS |
16:0 (palmitic acid) | 625.2 ± 99.7 | 419.6 ± 121.3 | NS | 108.4 ± 7.1 | 113.9 ± 10 | NS | 103.7 ± 5.7 | 98.3 ± 11.8 | NS | 105.9 ± 7.1 | 115.6 ± 6.8 | NS |
16:1n-7 (palmitoleic acid) | 67.1 ± 12.6 | 51.6 ± 12.7 | NS | 8.3 ± 0.8 | 14.6 ± 3.3 | 0.017 | 8.9 ± 0.8 | 6.7 ± 2 | NS | 10.7 ± 1.2 | 9.8 ± 2.9 | NS |
18:0 (stearic acid) | 182.8 ± 18.3 | 169.2 ± 22.8 | NS | 26.5 ± 1.9 | 24.6 ± 4.5 | NS | 23.4 ± 1.6 | 23.9 ± 4.8 | NS | 22.5 ± 1.9 | 24 ± 3.6 | NS |
18:1n-9 (oleic acid) | 671.8 ± 115.3 | 478.4 ± 71.4 | NS | 168.4 ± 17.5 | 172.7 ± 13.5 | NS | 178 ± 14.5 | 175.9 ± 18.2 | NS | 201.2 ± 15 | 217.6 ± 10.4 | NS |
18:2n-6 (linoleic acid) | 834.7 ± 100.9 | 727.4 ± 104.3 | NS | 103.2 ± 6.8 | 105.8 ± 17.6 | NS | 106.4 ± 5.5 | 99.1 ± 17.5 | NS | 118 ± 8.8 | 117 ± 11.7 | NS |
18:3n-3 (linolenic acid) | 30.2 ± 6.4 | 23.3 ± 6.6 | NS | 1.1 ± 0.3 | 0.4 ± 0.4 | NS | 0.6 ± 0.2 | 0.1 ± 0.1 | NS | 0.6 ± 0.2 | 0.2 ± 0.2 | NS |
18:4n-3 (octatetradecanonic acid) | N.D | N.D | NS | 2.8 ± 0.3 | 1.4 ± 0.6 | 0.026 | 2.2 ± 0.4 | 0.3 ± 0.3 | 0.026 | 2.1 ± 0.4 | 2.1 ± 0.8 | NS |
20:1n-9 (eicosenoic acid) | N.D | N.D | NS | 5.9 ± 0.6 | 5 ± 0.2 | NS | 6.6 ± 0.6 | 5.1 ± 0.8 | NS | 6 ± 0.5 | 6 ± 0.6 | NS |
20:3n-6 (eicosatrienoic acid) | 40.3 ± 5.6 | 42.5 ± 8.3 | NS | 2.0 ± 0.1 | 1.3 ± 0.4 | 0.038 | 1.6 ± 0.2 | 1.4 ± 0.3 | NS | 2.2 ± 0.2 | 2.3 ± 0.6 | NS |
20:4n-6 (arachidonic acid) | 136.8 ± 18 | 131 ± 19.4 | NS | 2.5 ± 0.3 | 1.9 ± 0.5 | NS | 1.7 ± 0.2 | 1.6 ± 0.3 | NS | 2.5 ± 0.3 | 1.8 ± 0.5 | NS |
20:5n-3 (eicosapentanoic acid) | N.D | N.D | NS | N.D | N.D | NS | N.D | N.D | NS | 0.4 ± 0.3 | 0.2 ± 0,1 | NS |
22:5n-3 (dokosapentaenoic acid) | N.D | N.D | NS | 1.4 ± 0.3 | 0.9 ± 0.4 | NS | 1.2 ± 0.3 | 0.4 ± 0.2 | NS | 0.6 ± 0.2 | 0.4 ± 0.2 | NS |
22:6n-3 (docosahexaenoic acid) | N.D | N.D | NS | 2 ± 0.4 | 1.3 ± 0.7 | NS | 2.8 ± 1.7 | 0.7 ± 0.4 | NS | 4.4 ± 1.8 | 1.8 ± 0.6 | NS |
24:1n-9 (nervonic acid) | 25 ± 4.6 | 33.6 ± 11.4 | NS | 1.9 ± 0.4 | 0.6 ± 0.4 | NS | 1.6 ± 0.4 | 0.7 ± 0.3 | NS | 1.6 ± 0.3 | 1.2 ± 0.4 | NS |
n-3 (ω − 3) | 35 ± 9.5 | 40.3 ± 9.2 | NS | 7.5 ± 0.6 | 4 ± 1.3 | 0.016 | 7 ± 1.7 | 1.6 ± 0.8 | NS | 8.1 ± 1.9 | 4.8 ± 0.6 | NS |
n-6 (ω − 6) | 1011.7 ± 115.3 | 900.9 ± 125.4 | NS | 107.6 ± 7 | 109 ± 18.2 | NS | 109.6 ± 5.7 | 102 ± 17.7 | NS | 122.8 ± 9 | 121.2 ± 12 | NS |
n-9 (ω − 9) | 681.8 ± 116.2 | 491.8 ± 76.4 | NS | 176.2 ± 18 | 178.4 ± 13.9 | NS | 186.2 ± 15 | 181.6 ± 19 | NS | 209 ± 15.2 | 224.9 ± 10.7 | NS |
Saturated | 840.7 ± 119.9 | 726.4 ± 107 | NS | 144.6 ± 9.2 | 150.3 ± 15.3 | NS | 137.2 ± 16.9 | 132 ± 17.7 | NS | 138.5 ± 9.1 | 150.1 ± 10.6 | NS |
Unsaturated | 1790.9 ± 237.4 | 1476.6 ± 205 | NS | 299.8 ± 20 | 306 ± 15.3 | NS | 311.7 ± 16.9 | 292 ± 36.8 | NS | 350.4 ± 19 | 360.5 ± 21 | NS |
Ratios | ||||||||||||
16:0 / 16:1 | 11 ± 1.1 | 11.1 ± 1.1 | NS | 14.8 ± 2 | 10.1 ± 2.7 | NS | 12.6 ± 0.9 | 11.8 ± 1.8 | NS | 11 ± 1 | 12.6 ± 1.5 | NS |
18:0 / 18:1 | 0.3 ± 0.03 | 0.4 ± 0.05 | NS | 0.2 ± 0.02 | 0.14 ± 0.03 | NS | 0.14 ± 0.02 | 0.12 ± 0.02 | NS | 0.11 ± 0.01 | 0.11 ± 0.01 | NS |
18:2 / 20:4 | 6.7 ± 0.7 | 5.7 ± 0.6 | NS | 41.3 ± 3.6 | 47.1 ± 5.6 | NS | 64.4 ± 6.6 | 64.5 ± 13.5 | NS | 49.2 ± 5.3 | 49.4 ± 4.7 | NS |
n-6 / n-3 | 50.3 ± 9.6 | 24.1 ± 4.4 | NS | 16.0 ± 1.5 | 26.8 ± 6.3 | 0.023 | 19.5 ± 2.3 | 43.5 ± 15.4 | 0.010 | 19.1 ± 2.3 | 25.6 ± 4.2 | NS |
Saturated / Unsaturated | 0.5 ± 0.02 | 0.5 ± 0.02 | NS | 0.5 ± 0.03 | 0.5 ± 0.04 | NS | 0.4 ± 0.02 | 0.4 ± 0.04 | NS | 0.4 ± 0.02 | 0.42 ± 0.03 | NS |