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Table 3 Fatty acid composition of serum, EAT, MAT and SAT of obese CAD group (n = 15) and controls (n = 5)

From: The role of mediastinal adipose tissue 11β-hydroxysteroid d ehydrogenase type 1 and glucocorticoid expression in the development of coronary atherosclerosis in obese patients with ischemic heart disease

  In SERUM   In EAT   In MAT   In SAT  
Fatty acids Obese CAD group (n = 15) Controls (n = 5) P value Obese CAD group (n = 15) Controls (n = 5) P value Obese CAD group (n = 15) Controls (n = 5) P value Obese CAD group (n = 15) Controls (n = 5) P value
14:0 (myristic acid) 32.7 ± 4.8 32.3 ± 7.9 NS 9.6 ± 0.8 11.9 ± 1.1 NS 10 ± 0.9 9.7 ± 1.4 NS 10.1 ± 0.7 10.4 ± 0.7 NS
16:0 (palmitic acid) 625.2 ± 99.7 419.6 ± 121.3 NS 108.4 ± 7.1 113.9 ± 10 NS 103.7 ± 5.7 98.3 ± 11.8 NS 105.9 ± 7.1 115.6 ± 6.8 NS
16:1n-7 (palmitoleic acid) 67.1 ± 12.6 51.6 ± 12.7 NS 8.3 ± 0.8 14.6 ± 3.3 0.017 8.9 ± 0.8 6.7 ± 2 NS 10.7 ± 1.2 9.8 ± 2.9 NS
18:0 (stearic acid) 182.8 ± 18.3 169.2 ± 22.8 NS 26.5 ± 1.9 24.6 ± 4.5 NS 23.4 ± 1.6 23.9 ± 4.8 NS 22.5 ± 1.9 24 ± 3.6 NS
18:1n-9 (oleic acid) 671.8 ± 115.3 478.4 ± 71.4 NS 168.4 ± 17.5 172.7 ± 13.5 NS 178 ± 14.5 175.9 ± 18.2 NS 201.2 ± 15 217.6 ± 10.4 NS
18:2n-6 (linoleic acid) 834.7 ± 100.9 727.4 ± 104.3 NS 103.2 ± 6.8 105.8 ± 17.6 NS 106.4 ± 5.5 99.1 ± 17.5 NS 118 ± 8.8 117 ± 11.7 NS
18:3n-3 (linolenic acid) 30.2 ± 6.4 23.3 ± 6.6 NS 1.1 ± 0.3 0.4 ± 0.4 NS 0.6 ± 0.2 0.1 ± 0.1 NS 0.6 ± 0.2 0.2 ± 0.2 NS
18:4n-3 (octatetradecanonic acid) N.D N.D NS 2.8 ± 0.3 1.4 ± 0.6 0.026 2.2 ± 0.4 0.3 ± 0.3 0.026 2.1 ± 0.4 2.1 ± 0.8 NS
20:1n-9 (eicosenoic acid) N.D N.D NS 5.9 ± 0.6 5 ± 0.2 NS 6.6 ± 0.6 5.1 ± 0.8 NS 6 ± 0.5 6 ± 0.6 NS
20:3n-6 (eicosatrienoic acid) 40.3 ± 5.6 42.5 ± 8.3 NS 2.0 ± 0.1 1.3 ± 0.4 0.038 1.6 ± 0.2 1.4 ± 0.3 NS 2.2 ± 0.2 2.3 ± 0.6 NS
20:4n-6 (arachidonic acid) 136.8 ± 18 131 ± 19.4 NS 2.5 ± 0.3 1.9 ± 0.5 NS 1.7 ± 0.2 1.6 ± 0.3 NS 2.5 ± 0.3 1.8 ± 0.5 NS
20:5n-3 (eicosapentanoic acid) N.D N.D NS N.D N.D NS N.D N.D NS 0.4 ± 0.3 0.2 ± 0,1 NS
22:5n-3 (dokosapentaenoic acid) N.D N.D NS 1.4 ± 0.3 0.9 ± 0.4 NS 1.2 ± 0.3 0.4 ± 0.2 NS 0.6 ± 0.2 0.4 ± 0.2 NS
22:6n-3 (docosahexaenoic acid) N.D N.D NS 2 ± 0.4 1.3 ± 0.7 NS 2.8 ± 1.7 0.7 ± 0.4 NS 4.4 ± 1.8 1.8 ± 0.6 NS
24:1n-9 (nervonic acid) 25 ± 4.6 33.6 ± 11.4 NS 1.9 ± 0.4 0.6 ± 0.4 NS 1.6 ± 0.4 0.7 ± 0.3 NS 1.6 ± 0.3 1.2 ± 0.4 NS
n-3 (ω − 3) 35 ± 9.5 40.3 ± 9.2 NS 7.5 ± 0.6 4 ± 1.3 0.016 7 ± 1.7 1.6 ± 0.8 NS 8.1 ± 1.9 4.8 ± 0.6 NS
n-6 (ω − 6) 1011.7 ± 115.3 900.9 ± 125.4 NS 107.6 ± 7 109 ± 18.2 NS 109.6 ± 5.7 102 ± 17.7 NS 122.8 ± 9 121.2 ± 12 NS
n-9 (ω − 9) 681.8 ± 116.2 491.8 ± 76.4 NS 176.2 ± 18 178.4 ± 13.9 NS 186.2 ± 15 181.6 ± 19 NS 209 ± 15.2 224.9 ± 10.7 NS
Saturated 840.7 ± 119.9 726.4 ± 107 NS 144.6 ± 9.2 150.3 ± 15.3 NS 137.2 ± 16.9 132 ± 17.7 NS 138.5 ± 9.1 150.1 ± 10.6 NS
Unsaturated 1790.9 ± 237.4 1476.6 ± 205 NS 299.8 ± 20 306 ± 15.3 NS 311.7 ± 16.9 292 ± 36.8 NS 350.4 ± 19 360.5 ± 21 NS
Ratios
16:0 / 16:1 11 ± 1.1 11.1 ± 1.1 NS 14.8 ± 2 10.1 ± 2.7 NS 12.6 ± 0.9 11.8 ± 1.8 NS 11 ± 1 12.6 ± 1.5 NS
18:0 / 18:1 0.3 ± 0.03 0.4 ± 0.05 NS 0.2 ± 0.02 0.14 ± 0.03 NS 0.14 ± 0.02 0.12 ± 0.02 NS 0.11 ± 0.01 0.11 ± 0.01 NS
18:2 / 20:4 6.7 ± 0.7 5.7 ± 0.6 NS 41.3 ± 3.6 47.1 ± 5.6 NS 64.4 ± 6.6 64.5 ± 13.5 NS 49.2 ± 5.3 49.4 ± 4.7 NS
n-6 / n-3 50.3 ± 9.6 24.1 ± 4.4 NS 16.0 ± 1.5 26.8 ± 6.3 0.023 19.5 ± 2.3 43.5 ± 15.4 0.010 19.1 ± 2.3 25.6 ± 4.2 NS
Saturated / Unsaturated 0.5 ± 0.02 0.5 ± 0.02 NS 0.5 ± 0.03 0.5 ± 0.04 NS 0.4 ± 0.02 0.4 ± 0.04 NS 0.4 ± 0.02 0.42 ± 0.03 NS
  1. All values are mean percent of total ± SE. Groups were compared with Mann–Whitney U test for the variables. Significant value, p < 0.05 (Obese CAD group vs. controls). Abbreviations: EAT: epicardial adipose tissue MAT: mediastinal adipose tissue, SAT: subcutaneous adipose tissue.