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Table 3 Linear regression analyses predicting six-month changes in brachial-ankle pulse-wave velocity in the SAVE trial

From: Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial

Predictor Unadjusted Associations1 Model 22 Model 33
  β 95% CI β 95% CI β 95% CI
Insulin Reduction −1.71** (−0.08, -3.34) −0.83 (0.77, -2.43) 3.71 (2.52, 5.00)
Weight Loss −2.14** (−0.32, -3.98) −1.55* (0.57, -3.61) −0.95 (−1.92 ,0.02)
Interaction -- -- -- -- −0.43*** (−0.31, -0.55)
  1. *P < 0.10, **P < 0.05, ***P < 0.001.
  2. 1 In the unadjusted model, the β term represents the predicted change in pulse-wave velocity (cm/s) per unit decrease in insulin (μU/mL) and weight (kg).
  3. 2 In the second column of multivariate models, the β term represents the predicted change in pulse-wave velocity (cm/s) per unit decrease in insulin (μU/mL) and weight (kg) when adjusting for age, sex, race, smoking status, mean arterial pressure, HDL cholesterol, triglycerides, CRP, baseline ba PWV and change in mean arterial pressure. This is one model with both weight loss and insulin change simultaneously plus covariates.
  4. 3 In the third column of multivariate models, the β term represents the predicted change in pulse-wave velocity (cm/s) for a simultaneous decrease in insulin (μU/mL) and weight (kg) when adjusting for age, sex, race, smoking status, mean arterial pressure, HDL cholesterol, triglycerides, CRP, baseline ba PWV and change in mean arterial pressure. This is one model with both weight loss and insulin change simultaneously plus their interaction plus covariates.
  5. ba PWV: brachial-ankle pulse-wave velocity.