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Table 2 Six-month changes in vascular stiffness and risk factors during the SAVE trial

From: Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial

  SAVE (N = 272)  
Vascular Stiffness Mean SD % Change
Δ ba PWV (cm/s), mixed −11.6† 91.5 −0.7
Δ fa PWV (cm/s), peripheral +5.8 91.9 +0.9
Δ cf PWV (cm/s), central −51.9† 303.3 −1.6
Potential Covariates   
Weight (kg) −7.0 5.9 −7.6
BMI (kg/m2) −2.0 2.0 −7.0
HDLc (mg/dL) 0.9 8.0 3.1
LDLc (mg/dL) −2.9 25.7 −0.3
Triglycerides (mg/dL) −18.7 60.1 −9.1
CRP (mg/dL) −1.0 4.9 −38.0
Fasting Insulin (μU/mL) −1.3 6.9 −0.7
Systolic BP, mm Hg −2.6 8.2 −2.0
Diastolic BP, mm Hg −1.5 7.7 −1.4
Mean Arterial Pressure −2.0 7.2 −1.9
  1. * Values reported represent the crude mean change from baseline PWV and the % change from baseline PWV.
  2. † change from zero, p < 0.05.
  3. ba PWV: brachial-ankle pulse-wave velocity.
  4. fa PWV: femoral-ankle pulse-wave velocity.
  5. cf PWV: carotid-femoral pulse-wave velocity.