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Table 1 Baseline risk factors and vascular stiffness in the SAVE trial

From: Effects of weight loss and insulin reduction on arterial stiffness in the SAVE trial

  All (N = 339) Women (N = 261) Men (N = 78)  
Risk Factor Mean SD Mean SD Mean SD P-Value
Age (years) 37.9 6.1 37.5 6.1 38.0 6.1 0.478
Weight (kg) 92.2 15.0 88.3 12.6 105.1 15.3 <0.001
BMI (kg/m2) 32.8 3.9 32.6 3.9 33.5 3.7 0.062
Heart Rate (bpm) 70.0 17.4 69.9 16.5 70.0 20.4 0.998
Total Cholesterol (mg/dL) 203.3 37.4 203.5 38.0 202.7 35.7 0.876
HDLc (mg/dL) 52.8 13.5 55.8 13.4 42.7 7.9 <.001
LDLc (mg/dL) 123.7 33.2 122.7 33.9 126.9 30.4 0.329
Triglycerides (mg/dL) 116 (78–170) 106 (76–155) 151 (110–209) <0.001
CRP (mg/dL) 2.6 (1.3-5.7) 2.9 (1.5-6.5) 2.2 (0.9-3.6) <0.001
Fasting Insulin (μU/mL) 14.6 8.1 14.0 6.8 16.5 11.2 0.069
HOMA-IR 3.6 2.1 3.4 1.8 4.1 2.9 0.045
Systolic BP, mm Hg 113.3 10.5 112.2 10.6 117.1 9.1 <.001
Diastolic BP, mm Hg 72.9 8.7 71.8 8.6 76.5 8.1 <.001
Mean Arterial Pressure 93.1 8.9 92.0 8.9 96.8 7.9 <.001
Ankle-Brachial Index 1.06 0.07 1.05 0.07 1.08 0.07 0.002
Race – n,%        0.013
White 273 80.5% 205 78.5% 68 87.2%  
Black 54 15.9% 49 18.8% 5 6.4%  
Other 12 3.5% 7 2.7% 5 6.4%  
Smoking Status – n,%        0.067
Never 211 62.2% 155 59.4% 56 71.8%  
Former 96 28.4% 82 31.4% 14 17.9%  
Current 32 9.4% 24 9.2% 8 10.3%  
Vascular Stiffness Mean SD Mean SD Mean SD  
Mixed, ba PWV (cm/sec) 1207.6 132.3 1194.2 126.0 1252.3 143.6 <.001
Peripheral, fa PWV (cm/sec) 945.9 102.8 942.9 98.2 956.1 117.5 0.385
Central, cf PWV (cm/sec) 880.0 257.4 864.6 247.8 932.3 283.1 0.046
  1. * Values reported are mean ± SD unless otherwise noted.
  2. Reported as Median (Q1-Q3) due to skewed distribution.
  3. Denotes test for difference between men and women.
  4. HOMA-IR: Homeostatic Insulin Resistance, CRP: C - reactive protein; ba PWV: brachial-ankle pulse-wave velocity (n = 339); fa PWV: femoral-ankle pulse-wave velocity (n = 320); cf PWV: carotid-femoral pulse-wave velocity (n = 324).