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Table 1 Patient characteristics and co-morbidity at baseline

From: Ramipril-based versus diuretic-based antihypertensive primary treatment in patients with pre-diabetes (ADaPT) study

  Intention to treat Per protocol
  Ramipril
(n = 1,350)
Diuretic
(n = 661)
Ramipril
(n = 1,029)
Diuretic
(n = 478)
Age (years ± SD) 69.4 ± 10.4 68.5 ± 10.3 69.4 ± 10.5 67.8 ± 10.3
Female (%) 48.7 57.5 48.5 58.4
BMI (kg/m2 ± SD) 29.9 ± 5.0 29.8 ± 4.8 29.8 ± 5.0 29.7 ± 4.9
Risk factors*     
   Dyslipidemia (%) 56.4 56.6 54.7 56.9
   Hyperuricemia (%) 21.7 23.0 20.5 20.5
   CAD (%) 13.9 14.2 11.7 13.6
   COPD (%) 6.7 4.8 6.8 5.4
   Microalbuminuria (%) 6.2 5.4 6.2 5.6
   Kidney disease (%) 3.0 2.9 2.8 2.1
   Smoking (%) 15.6 14.4 15.6 14.4
Diabetes     
   Diabetes (%) 0 0 0 0
   Family history (%) 37.0 40.4 37.2 41.4
Laboratory values     
   Total cholesterol (mg/dl ± SD) 222.4 ± 43.4 222.5 ± 41.8 223.4 ± 42.0 224.1 ± 41.9
   HDL-cholesterol (mg/dl ± SD) 61.7 ± 16.0 61.8 ± 15.3 62.5 ± 16.1 61.7 ± 15.6
   LDL-cholesterol (mg/dl ± SD) 128.6 ± 35.6 127.2 ± 34.2 129.3 ± 35.4 128.6 ± 34.1
   Triglycerides (mg/dl ± SD) 169.1 ± 168.3 172.8 ± 127.5 161.8 ± 97.8 175.2 ± 137.6
Fasting blood glucose
(mg/dl ± SD)
94.4 ± 21.3 95.5 ± 21.0 94.1 ± 21.3 95.7 ± 21.5
   HbA1c (% ± SD) 5.6 ± 0.6 5.7 ± 0.7 5.6 ± 0.6 5.6 ± 0.7
   Serum-creatinine (mg/dl ± SD) 1.0 ± 0.3 1.0 ± 0.3 1.0 ± 0.3 1.0 ± 0.3
Albuminuria
(mg/g creatinine ± SD)
33.1 ± 121.6 24.6 ± 56.3 33.8 ± 131.4 19.4 ± 38.2
   Urinary creatinine (mg/dl ± SD) 123.6 ± 72.7 122.7 ± 74.0 123.3 ± 72.4 120.6 ± 71.6
   Cystatin-C (mg/dl ± SD) 1.0 ± 0.3 1.0 ± 0.3 1.0 ± 0.3 1.0 ± 0.3
   hs-CRP (mg/dl ± SD) 5.2 ± 8.7 5.3 ± 14.2 5.1 ± 8.5 5.6 ± 16.0
  1. Legend. * available cases only (about 12% for microalbuminuria, about 1% for the other variables); SD, standard deviation; BMI, body mass index; CAD, coronary artery disease; COPD, chronic obstructive pulmonary disease; HDL, high density lipoprotein; LDL, low density lipoprotein; CRP, C-reactive protein