Intention to treat | Per protocol | |||
---|---|---|---|---|
Ramipril (n = 1,350) | Diuretic (n = 661) | Ramipril (n = 1,029) | Diuretic (n = 478) | |
Age (years ± SD) | 69.4 ± 10.4 | 68.5 ± 10.3 | 69.4 ± 10.5 | 67.8 ± 10.3 |
Female (%) | 48.7 | 57.5 | 48.5 | 58.4 |
BMI (kg/m2 ± SD) | 29.9 ± 5.0 | 29.8 ± 4.8 | 29.8 ± 5.0 | 29.7 ± 4.9 |
Risk factors* | ||||
Dyslipidemia (%) | 56.4 | 56.6 | 54.7 | 56.9 |
Hyperuricemia (%) | 21.7 | 23.0 | 20.5 | 20.5 |
CAD (%) | 13.9 | 14.2 | 11.7 | 13.6 |
COPD (%) | 6.7 | 4.8 | 6.8 | 5.4 |
Microalbuminuria (%) | 6.2 | 5.4 | 6.2 | 5.6 |
Kidney disease (%) | 3.0 | 2.9 | 2.8 | 2.1 |
Smoking (%) | 15.6 | 14.4 | 15.6 | 14.4 |
Diabetes | ||||
Diabetes (%) | 0 | 0 | 0 | 0 |
Family history (%) | 37.0 | 40.4 | 37.2 | 41.4 |
Laboratory values | ||||
Total cholesterol (mg/dl ± SD) | 222.4 ± 43.4 | 222.5 ± 41.8 | 223.4 ± 42.0 | 224.1 ± 41.9 |
HDL-cholesterol (mg/dl ± SD) | 61.7 ± 16.0 | 61.8 ± 15.3 | 62.5 ± 16.1 | 61.7 ± 15.6 |
LDL-cholesterol (mg/dl ± SD) | 128.6 ± 35.6 | 127.2 ± 34.2 | 129.3 ± 35.4 | 128.6 ± 34.1 |
Triglycerides (mg/dl ± SD) | 169.1 ± 168.3 | 172.8 ± 127.5 | 161.8 ± 97.8 | 175.2 ± 137.6 |
Fasting blood glucose (mg/dl ± SD) | 94.4 ± 21.3 | 95.5 ± 21.0 | 94.1 ± 21.3 | 95.7 ± 21.5 |
HbA1c (% ± SD) | 5.6 ± 0.6 | 5.7 ± 0.7 | 5.6 ± 0.6 | 5.6 ± 0.7 |
Serum-creatinine (mg/dl ± SD) | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 |
Albuminuria (mg/g creatinine ± SD) | 33.1 ± 121.6 | 24.6 ± 56.3 | 33.8 ± 131.4 | 19.4 ± 38.2 |
Urinary creatinine (mg/dl ± SD) | 123.6 ± 72.7 | 122.7 ± 74.0 | 123.3 ± 72.4 | 120.6 ± 71.6 |
Cystatin-C (mg/dl ± SD) | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 | 1.0 ± 0.3 |
hs-CRP (mg/dl ± SD) | 5.2 ± 8.7 | 5.3 ± 14.2 | 5.1 ± 8.5 | 5.6 ± 16.0 |