Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

Table 3 Adjusted odds ratios for the association between CAC progression and Hp genotype, stratified by presence of CAC at baseline

		Adjusting for age and sex only			Including covariates from backwards selection model*
Characteristic		OR	95% CI	p -value	OR	95% CI	p -value
Hp genotype * diabetes interaction*presence of CAC at baseline interaction		N/A		0.03	N/A		0.09
CAC not present at the baseline visit	Hp 2-2 vs. 2-1/1-1 in patients with diabetes	2.03	1.13-3.65	0.02	1.95	1.07-3.56	0.03
	Hp 2-2 vs. 2-1/1-1 in controls without diabetes	0.83	0.37-1.84	0.65	0.69	0.38-1.27	0.94
CAC present at the baseline visit	Hp 2-2 vs. 2-1/1-1 in patients with diabetes	0.68	0.37-1.24	0.21	0.80	0.33-1.93	0.22
	Hp 2-2 vs. 2-1/1-1 in controls without diabetes	1.33	0.94-3.28	0.07	1.17	0.49-2.81	0.29
Age		1.08	1.05-1.10	< 0.0001	1.08	1.05-1.10	0.009
Female vs. male		0.43	0.31-0.60	< 0.0001	0.65	0.45-0.94	< 0.0001
Systolic blood pressure		N/A			1.03	1.02-1.05	< 0.0001
HDL cholesterol		N/A			0.97	0.96-0.99	0.0001
Square root CAC volume at baseline		N/A			1.25	1.13-1.38	< 0.0001

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