Skip to main content

Table 3 Adjusted odds ratios for the association between CAC progression and Hp genotype, stratified by presence of CAC at baseline

From: Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

   Adjusting for age and sex only Including covariates from backwards selection model*
Characteristic   OR 95% CI p -value OR 95% CI p -value
Hp genotype * diabetes interaction*presence of CAC at baseline interaction   N/A 0.03 N/A 0.09
   CAC not present at the baseline visit Hp 2-2 vs. 2-1/1-1 in patients with diabetes 2.03 1.13-3.65 0.02 1.95 1.07-3.56 0.03
  Hp 2-2 vs. 2-1/1-1 in controls without diabetes 0.83 0.37-1.84 0.65 0.69 0.38-1.27 0.94
   CAC present at the baseline visit Hp 2-2 vs. 2-1/1-1 in patients with diabetes 0.68 0.37-1.24 0.21 0.80 0.33-1.93 0.22
  Hp 2-2 vs. 2-1/1-1 in controls without diabetes 1.33 0.94-3.28 0.07 1.17 0.49-2.81 0.29
Age   1.08 1.05-1.10 < 0.0001 1.08 1.05-1.10 0.009
Female vs. male   0.43 0.31-0.60 < 0.0001 0.65 0.45-0.94 < 0.0001
Systolic blood pressure   N/A 1.03 1.02-1.05 < 0.0001
HDL cholesterol   N/A 0.97 0.96-0.99 0.0001
Square root CAC volume at baseline   N/A 1.25 1.13-1.38 < 0.0001
  1. * Adjusting for age, sex, systolic blood pressure and HDL-cholesterol