Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

Table 2 Adjusted β estimates from linear regression analyzing the association between Hp genotype and square root transformed CAC volume, stratified by the presence of CAC at baseline

		Adjusting for age and sex only		Including covariates from backwards selection model*
Characteristic		β estimate	p -value	β estimate	p -value
Hp genotype * diabetes interaction*presence of CAC at baseline interaction		N/A	0.001	N/A	0.001
CAC not present at the baseline visit	Hp 2-2 vs. 2-1/1-1 in patients with diabetes	0.82	0.03	0.74	0.05
	Hp 2-2 vs. 2-1/1-1 in controls without diabetes	0.67	0.2	0.83	0.11
CAC present at the baseline visit	Hp 2-2 vs. 2-1/1-1 in patients with diabetes	-0.34	0.3	-0.31	0.33
	Hp 2-2 vs. 2-1/1-1 in controls without diabetes	-2.02	0.52	0.24	0.7
Age		0.11	< 0.0001	0.1	< 0.0001
Female vs. male		-1.17	< 0.0001	0.22	0.001
Systolic blood pressure		N/A		0.01	< 0.0001
HDL cholesterol		N/A		0.01	0.003

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