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Table 1 Baseline characteristics in study subjects with 6 year progression data and Hp genotype data by diabetes status

From: Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes

Characteristic

Study subjects with type 1 diabetes

 

Control subjects without type 1 diabetes

 
 

6 Year CAC Progression ≥ 2.5

6 Year CAC Progression < 2.5

 

6 Year CAC Progression ≥ 2.5

6 Year CAC Progression < 2.5

 
 

n = 178

n = 258

 

n = 150

n = 376

 

CAC present at baseline visit

113(63)

37(14)

*

86(57)

51(14)

*

Haptoglobin genotype 2-2

76(43)

89(35)

 

46(31)

139(37)

 

Mean 6 year change in CAC volume

7.4 ± 4.4

0.4 ± 0.8

*

5.8 ± 3.1

0.3 ± 0.7

*

Female

78(44)

160(62)

*

41(27)

223(59)

*

Mean age (years)

40.1 ± (8.1)

34.0 ± 8.2)

*

45.2 ± 7.3)

39.0 ± 8.5

*

Mean diastolic blood pressure (mmHg)

78.0 ± 9.0

76.3 ± 8.4

*

83.2 ± 8.9

77.2 ± 7.6

*

Mean systolic blood pressure (mmHg)

120.2 ± 13.6

113.9 ± 12.1

*

120.4 ± 12.7

111.6 ± 11.1

*

Mean body mass index (kg/m2)

26.7 ± 4.3

25.6 ± 4.0

*

28.2 ± 4.8

25.3 ± 4.4

*

Mean LDL cholesterol (mmol/l)

2.7 ± 0.73

2.5 ± 0.7

*

3.1 ± 0.8

3.0 ± 0.8

*

Mean HDL cholesterol (mmol/l)

1.4 ± 0.4

1.5 ± 0.4

*

1.2 ± 0.3

1.4 ± 0.4

*

Mean triglycerides (mmol/l)

1.1 ± 0.01

1.0 ± 0.5

*

1.8 ± 1.2

1.3 ± 0.7

*

Mean HbA1c (%)

8.0 ± 1.2

7.8 ± 1.2

 

5.6 ± 0.4

5.4 ± 0.4

*

Ever smoker

48(27)

39(15)

*

27(18)

86(23)

 
  1. * p-value less than 0.05 comparing CAC progression in individuals with type 1 diabetes and control subjects separately
  2. Data are presented as mean ± sd or as n (%)
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Cardiovascular Diabetology

ISSN: 1475-2840