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Table 2 Structural, histological and immunohistochemical characteristics of mesenteric resistance arteries:

From: Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report

  ZL ZL+S ZDF ZDF+E ZDF+S ZDF+S+E ZDF+S+H P-value
Media (μm) 17.9 ± 0.9 22.2 ± 1.9 19.8 ± 0.9 21.1 ± 1.1 28.7 ± 1.8 22.6 ± 2.0 23.6 ± 1.2 < 0.001
Lumen (μm) 297 ± 14 306 ± 22 298 ± 11 301 ± 21 273 ± 12 305 ± 13 302 ± 17 0.82
Media/Lumen (%) 6.1 ± 0.3 7.3 ± 0.3 6.7 ± 0.3 7.1 ± 0.3 10.7 ± 0.8♠ 7.5 ± 0.7 7.9 ± 0.4 < 0.001
Exponent
Strain/stress relation
6.4 ± 0.4 6.3 ± 0.3 6.5 ± 0.5 5.7 ± 0.3 7.5 ± 0.6 5.6 ± 0.3 6.4 ± 0.7 0.09
Collagen IV (%) 17.1 ± 0.7 25.9 ± 0.4* 20.9 ± 0.7§ 18.3 ± 0.4¥¥ 27.0 ± 0.4¥ 21.3 ± 0.4¡ 21.5 ± 0.5¡ ¡ < 0.001
Elastin (%) 21.6 ± 1.3 15.6 ± 1.2 18.8 ± 1.2 23.5 ± 1.4 17.6 ± 2.0 18.0 ± 1.2 19.2 ± 0.6 0.01
Sirius red (%) 12.1 ± 0.4 19.0 ± 0.9 16.2 ± 0.6 17.2 ± 0.6 19.6 ± 0.6 17.5 ± 0.9 17.1 ± 0.7✚ < 0.001
  1. Abbreviations: ZL: Zucker lean on normal diet. ZL + S: Zucker lean on high salt diet. ZDF: Zucker diabetic fatty. ZDF + E: Zucker diabetic fatty on eplerenone therapy. ZDF + S: Zucker diabetic fatty on high salt diet. ZDF + S + E: Zucker diabetic fatty on high salt diet with eplerenone therapy. ZDF + S + H: Zucker diabetic fatty on high salt diet with hydralazine therapy.
  2. Post hoc testing: * P < 0.001 ZL vs. ZL+S. § P < 0.001 ZL vs. ZDF. ¥ P < 0.001 ZDF vs. ZDF+S. ¥¥ p < 0.001 ZDF vs. ZDF+E. ¡ P < 0.001 ZDF+S vs. ZDF+S+E. ¡ ¡ p < 0.001 ZDF+S vs. ZDF+S+H. P < 0.05 ZDF+S vs. all other groups. ♠ P < 0.001 ZDF+S vs. all other groups. P < 0.05 ZDF vs. ZDF + S. ✚ p < 0.05 ZDF + S vs. ZDF + S + H.