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Table 2 Data of LETO rats and OLETF rats fed on tap water at the time of 22 weeks old (4 weeks after G-CSF or saline treatment)

From: Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats

 

LETO (-)

(n = 8)

OLETF (-/-)

(n = 4)

OLETF (-/+)

(n = 2)

p

BW (g)

444.0 ± 15.2

600.2 ± 31.2*

537.5 ± 95.5**

< 0.001

FBG (mg/dl)

210.8 ± 46.6

364.0 ± 120.0**

281.0 ± 89.1

0.025

TC (mg/dl)

55.4 ± 6.9

61.5 ± 7.6

61.0 ± 12.7

0.397

TG (mg/dl)

45.9 ± 12.5

151.0 ± 62.0*

162.0 ± 46.7*

0.001

HR (bpm)

292.9 ± 18.1

283.5 ± 28.3

291.0 ± 24.0

0.785

E (cm/sec)

79.5 ± 4.2

73.6 ± 2.2

75.2 ± 0.4

0.051

E' (cm/sec)

7.1 ± 0.5

5.7 ± 0.3*

6.7 ± 0.4

0.001

E/E'

11.2 ± 0.6

12.9 ± 0.7*

11.3 ± 0.7‡

0.004

DT (msec)

76.4 ± 5.5

68.5 ± 12.8

73.5 ± 0.7

0.311

BP (mmHg)

160.0 ± 14.1

167.2 ± 10.1

167.4 ± 34.8

0.950

  1. Values are mean ± SD. *p < 0.01 and **p < 0.05 versus LETO (-). †p < 0.01 and ‡p < 0.05 versus OLETF (-/-).
  2. LETO; Long-Evans Tokushima Otsuka rat, OLETF; Otsuka Long-Evans Tokushima Fatty rat, G-CSF; granulocyte-colony stimulating factor, BW; body weight, FBG; fasting blood glucose, TC; total cholesterol, TG; triglyceride, HR; Heart rate, E; peak velocity of the early diastolic filling wave, E'; early mitral annulus velocity, DT; deceleration time BP; blood pressure,
  3. LETO (-); LETO rats fed on tap water,
  4. OLETF (-/-); OLETF rats fed on tap water and treated with saline,
  5. OLETF (-/+); OLETF rats fed on tap water and treated with G-CSF
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Cardiovascular Diabetology

ISSN: 1475-2840