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Table 1 Baseline data before treatment with G-CSF or saline (at the time of 17 weeks old)

From: Effects of granulocyte-colony stimulating factor (G-CSF) on diabetic cardiomyopathy in Otsuka Long-Evans Tokushima Fatty rats

 

LETO (-)

(n = 8)

OLETF (-)

(n = 7)

OLETF (+)

(n = 12)

p

BW (g)

428 ± 18.8

551.4 ± 44.9*

595.7 ± 37.5*‡

< 0.001

FBG (mg/dl)

125.4 ± 9.8

148.0 ± 28.5

151.3 ± 34.5

0.129

TC (mg/dl)

71.9 ± 19.8

97.3 ± 25.0**

89.8 ± 15.1

0.045

TG (mg/dl)

46.6 ± 23.4

197.7 ± 91.2**

190.7 ± 41.6*

< 0.001

HR (bpm)

312.9 ± 18.7

297.6 ± 24.5

298.8 ± 12.2

0.177

E (cm/sec)

72.8 ± 3.3

66.3 ± 1.7**

65.5 ± 5.4*

0.002

E' (cm/sec)

9.0 ± 1.4

6.7 ± 0.2*

5.2 ± 0.3*†

< 0.001

E/E'

8.2 ± 1.0

9.8 ± 0.4*

12.5 ± 0.8*†

< 0.001

DT (msec)

81.8 ± 12.3

83.6 ± 9.5

86.3 ± 11.4

0.675

  1. Values are mean ± SD. *p < 0.01 and **p < 0.05 versus LETO (-). †p < 0.01 and ‡p < 0.05 versus OLETF (-).
  2. LETO; Long-Evans Tokushima Otsuka rat, OLETF; Otsuka Long-Evans Tokushima Fatty rat, BW; body weight, FBG; fasting blood glucose TC; total cholesterol, TG; triglyceride, HR; Heart rate, E; peak velocity of the early diastolic filling wave, E'; early mitral annulus velocity, DT; deceleration time, LETO (-); LETO rats fed on tap water, OLETF (-); OLETF rats fed on tap water, OLETF (+); OLETF rats fed on sucrose contained water
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Cardiovascular Diabetology

ISSN: 1475-2840