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Table 1 Baseline characteristics of the patients randomized to carvedilol, metoprolol succinate and metoprolol tartrate before and after the treatment period, and baseline characteristics of the healthy control group

From: Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure-a randomized study

 

Carvedilol

(N = 9)

Metoprolol Succinate

(N = 9)

Metoprolol Tartrate

(N = 9)

Healthy controls

(N = 10)

 

Before treatment

After treatment

Before treatment

After trreatment

Before treatment

After treatment

 

Age

67.1 ± 3.31

63.6 ± 2.02

60.3 ± 3.26

47.6 ± 1.89

Sex (Female/Male)

2/7

2/7

1/8

5/5

Smokers (Y/N)

4/5

1/8

2/7

0

Diabetes (Y/N)

3/6

3/6

0/9

0

NYHA I (N°)

5

4

5

0

NYHA II (N°)

4

5

4

0

ACE I/ATII ant (Y/N)

9/0

7/2

5/4

0

Aspirin (Y/N)

6/3

6/3

7/2

0

Statins (Y/N)

7/2

8/1

7/2

0

CRP

< 10

< 10

< 10

< 10

< 10

< 10

< 10

Hgb (mmol/l)

8.1 ± 0.30

7.97 ± 0.34

8.48 ± 0.23

8.37 ± 0.33

8.54 ± 0.19

8.47 ± 0.16

8.00 ± 0.21

Total Cholesterol (mmol/l)

3.88 ± 0.23

3.89 ± 0.30

4.21 ± 0.27

3.96 ± 0.22

3.88 ± 0.18

3.81 ± 0.19

4.5 ± 0.29

Triglyceride (mmol/l)

1.57 ± 0.40

1.35 ± 0.20

1.66 ± 0.41

1.74 ± 0.31

1.57 ± 0.38

1.57 ± 0.36

0.9 ± 0.17

HDL (mmol/l)

1.47 ± 0.20

1.24 ± 0.203

1.44 ± 0.16

1.15 ± 0.113

1.34 ± 0.12

1.27 ± 0.13

1.4 ± 0.14

LDL (mmol/l)

1.88 ± 0.17

2.03 ± 0.24

2.24 ± 0.31

2.03 ± 0.24

1.80 ± 0.24

1.88 ± 0.27

2.7 ± 0.26

Hgb A1c (%)

6.12 ± 0.20

5.91 ± 0.233

6.78 ± 0.49

6.73 ± 0.51

5.64 ± 0.10¹2

5.5 ± 0.252

5.24 ± 0.10

Plasma-Glucose

6.30 ± 0.29

6.24 ± 0.69

5.73 ± 0.42

5.82 ± 0.49

5.19 ± 0.26¹

5.14 ± 0.31

 

Serum-Insulin

24.80 ± 11.72

27.50 ± 12.96

9.72 ± 2.52

17.67 ± 4.71

8.52 ± 2.93

8.32 ± 3.48

 

HOMA-IR

1.86 ± 0.67

1.77 ± 0.37

1.33 ± 0.34

1.87 ± 0.62

1.11 ± 0.40

1.33 ± 0.56

 

Body weight (kg)

77.58 ± 6.60

77.47 ± 6.74

90.21 ± 6.17

90.19 ± 6.40

86.82 ± 3.53

87.59 ± 3.99

75.62 ± 4.24

BMI (kg/m 2 )

26.37 ± 1.23

26.32 ± 1.27

29.41 ± 1.63

29.38 ± 1.65

28.1 ± 0.84

28.31 ± 0.98

24.4 ± 0.93

  1. ¹p < 0.05 for comparison between metoprolol tartrate and carvedilol
  2. 2p < 0.05 for comparison between metoprolol tartrate and metoprolol succinate
  3. 3p < 0.05 change from before and after randomization treatment