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Table 1 Baseline characteristics of the patients randomized to carvedilol, metoprolol succinate and metoprolol tartrate before and after the treatment period, and baseline characteristics of the healthy control group

From: Endothelial function is unaffected by changing between carvedilol and metoprolol in patients with heart failure-a randomized study

  Carvedilol
(N = 9)
Metoprolol Succinate
(N = 9)
Metoprolol Tartrate
(N = 9)
Healthy controls
(N = 10)
  Before treatment After treatment Before treatment After trreatment Before treatment After treatment  
Age 67.1 ± 3.31 63.6 ± 2.02 60.3 ± 3.26 47.6 ± 1.89
Sex (Female/Male) 2/7 2/7 1/8 5/5
Smokers (Y/N) 4/5 1/8 2/7 0
Diabetes (Y/N) 3/6 3/6 0/9 0
NYHA I (N°) 5 4 5 0
NYHA II (N°) 4 5 4 0
ACE I/ATII ant (Y/N) 9/0 7/2 5/4 0
Aspirin (Y/N) 6/3 6/3 7/2 0
Statins (Y/N) 7/2 8/1 7/2 0
CRP < 10 < 10 < 10 < 10 < 10 < 10 < 10
Hgb (mmol/l) 8.1 ± 0.30 7.97 ± 0.34 8.48 ± 0.23 8.37 ± 0.33 8.54 ± 0.19 8.47 ± 0.16 8.00 ± 0.21
Total Cholesterol (mmol/l) 3.88 ± 0.23 3.89 ± 0.30 4.21 ± 0.27 3.96 ± 0.22 3.88 ± 0.18 3.81 ± 0.19 4.5 ± 0.29
Triglyceride (mmol/l) 1.57 ± 0.40 1.35 ± 0.20 1.66 ± 0.41 1.74 ± 0.31 1.57 ± 0.38 1.57 ± 0.36 0.9 ± 0.17
HDL (mmol/l) 1.47 ± 0.20 1.24 ± 0.203 1.44 ± 0.16 1.15 ± 0.113 1.34 ± 0.12 1.27 ± 0.13 1.4 ± 0.14
LDL (mmol/l) 1.88 ± 0.17 2.03 ± 0.24 2.24 ± 0.31 2.03 ± 0.24 1.80 ± 0.24 1.88 ± 0.27 2.7 ± 0.26
Hgb A1c (%) 6.12 ± 0.20 5.91 ± 0.233 6.78 ± 0.49 6.73 ± 0.51 5.64 ± 0.10¹2 5.5 ± 0.252 5.24 ± 0.10
Plasma-Glucose 6.30 ± 0.29 6.24 ± 0.69 5.73 ± 0.42 5.82 ± 0.49 5.19 ± 0.26¹ 5.14 ± 0.31  
Serum-Insulin 24.80 ± 11.72 27.50 ± 12.96 9.72 ± 2.52 17.67 ± 4.71 8.52 ± 2.93 8.32 ± 3.48  
HOMA-IR 1.86 ± 0.67 1.77 ± 0.37 1.33 ± 0.34 1.87 ± 0.62 1.11 ± 0.40 1.33 ± 0.56  
Body weight (kg) 77.58 ± 6.60 77.47 ± 6.74 90.21 ± 6.17 90.19 ± 6.40 86.82 ± 3.53 87.59 ± 3.99 75.62 ± 4.24
BMI (kg/m 2 ) 26.37 ± 1.23 26.32 ± 1.27 29.41 ± 1.63 29.38 ± 1.65 28.1 ± 0.84 28.31 ± 0.98 24.4 ± 0.93
  1. ¹p < 0.05 for comparison between metoprolol tartrate and carvedilol
  2. 2p < 0.05 for comparison between metoprolol tartrate and metoprolol succinate
  3. 3p < 0.05 change from before and after randomization treatment