Skip to main content

Table 3 Hemodynamic parameters of the experimental groups at sacrifice (12 weeks).

From: Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure

  Sham
N = 8
MI
N = 10
MI-VI
N = 9
MI-VL
N = 9
Heart rate (bpm) 346 ± 16 378 ± 7 350 ± 9 361 ± 12
LVESP (mmHg) 117 ± 4 109 ± 3 108 ± 3 109 ± 4
LVEDP (mmHg) 6.2 ± 0.8 9.6 ± 1.6* 9.8 ± 1.3* 7.4 ± 0.5
SBP (mmHg) 115 ± 3 111 ± 2 110 ± 3 113 ± 3
DBP (mmHg) 87 ± 2 86 ± 2 85 ± 2 84 ± 2
dPdtmax (mmHg/s) 8744 ± 435 7245 ± 436 6908 ± 396 7952 ± 484
dPdtmin (mmHg/s) -9363 ± 268 -6419 ± 466* -6592 ± 613* -7077 ± 380*
  1. Data are presented as means ± SEM; N indicates number of animals; LVESP, left ventricular end-systolic pressure; LVEDP, left ventricular end-diastolic pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; dP/dt max and dP/dt min, the maximal rate of increase and decrease of left ventricular pressure, respectively.*P < 0.05 vs. Sham.