Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure

Table 3 Hemodynamic parameters of the experimental groups at sacrifice (12 weeks).

	Sham N = 8	MI N = 10	MI-VI N = 9	MI-VL N = 9
Heart rate (bpm)	346 ± 16	378 ± 7	350 ± 9	361 ± 12
LVESP (mmHg)	117 ± 4	109 ± 3	108 ± 3	109 ± 4
LVEDP (mmHg)	6.2 ± 0.8	9.6 ± 1.6*	9.8 ± 1.3*	7.4 ± 0.5
SBP (mmHg)	115 ± 3	111 ± 2	110 ± 3	113 ± 3
DBP (mmHg)	87 ± 2	86 ± 2	85 ± 2	84 ± 2
dPdtmax (mmHg/s)	8744 ± 435	7245 ± 436	6908 ± 396	7952 ± 484
dPdtmin (mmHg/s)	-9363 ± 268	-6419 ± 466*	-6592 ± 613*	-7077 ± 380*

Data are presented as means ± SEM; N indicates number of animals; LVESP, left ventricular end-systolic pressure; LVEDP, left ventricular end-diastolic pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; dP/dt max and dP/dt min, the maximal rate of increase and decrease of left ventricular pressure, respectively.*P < 0.05 vs. Sham.