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Table 2 Echocardiographic parameters of the experimental groups at week 3 and week 12.

From: Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure

  Week 3 Week 12
  Sham MI MI+VI MI+VL Sham MI MI+VI MI+VL
  N = 8 N = 10 N = 9 N = 9 N = 8 N = 10 N = 9 N = 9
HR (bpm) 377 ± 11 379 ± 9 383 ± 11 407 ± 11 370 ± 12 387 ± 6 377 ± 10 391 ± 6
IVSd(mm) 1.5 ± 0.1 0.9 ± 0.1** 1.0 ± 0.01* 1.0 ± 0.1* 1.6 ± 0.1 0.8 ± 0.1** 1.0 ± 0.1* 0.8 ± 0.1**
LVIDd(mm) 7.7 ± 0.1 8.3 ± 0.3 8.4 ± 0.2 8.1 ± 0.3 8.0 ± 0.4 10.1 ± 0.3** § 9.7 ± 0.4** § 9.7 ± 0.2 ** §
LVPWd(mm) 1.8 ± 0.1 1.8 ± 0.1 1.9 ± 0.1 1.8 ± 0.1 2.1 ± 0.2 2.3 ± 0.2 2.0 ± 0.12 2.0 ± 0.1
IVSs(mm) 2.9 ± 0.1 1.3 ± 0.2* 2.0 ± 0.6 1.3 ± 0.2* 2.9 ± 0.2 1.0 ± 0.2** 1.2 ± 0.2** 1.2 ± 0.2**
LVIDs(mm) 4.2 ± 0.1 6.5 ± 0.3** 6.0 ± 0.4** 6.3 ± 0.3** 4.6 ± 0.4 8.6 ± 0.5** § 7.7 ± 0.4** 7.6 ± 0.2** §
LVPWs(mm) 2.9 ± 0.1 2.7 ± 0.1 2.6 ± 0.2 2.5 ± 0.1 2.9 ± 0.2 2.7 ± 0.3 2.6 ± 0.1 2.6 ± 0.2
LVEF (%) 82 ± 1 49 ± 3** 48 ± 4** 49 ± 3** 78 ± 3 36 ± 5** § 45 ± 5** 48 ± 4**
FS (%) 46 ± 2 22 ± 2** 21 ± 2** 22 ± 2** 43 ± 3 16 ± 3**§ 21 ± 2** 22 ± 2**
  1. Data are presented as means ± SEM; N indicates number of animals; bpm, beats per minute. **P < 0.01 and *P < 0.05 indicate significant differences compared to sham-operated rats in week 3 and week 12 respectively; § P < 0.05 indicates significant difference between parameters at week 12 and week 3 using Paired-Sample T-Test. IVSd and IVSs, the thickness of the interventricular septum in diastole and systole; LVIDd and LVIDs, diastolic and systolic left ventricle dimensions; LVPWd and LVPWs, the thickness of left ventricle posterior wall in diastole and systole.