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Table 2 Echocardiographic parameters of the experimental groups at week 3 and week 12.

From: Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure

 

Week 3

Week 12

 

Sham

MI

MI+VI

MI+VL

Sham

MI

MI+VI

MI+VL

 

N = 8

N = 10

N = 9

N = 9

N = 8

N = 10

N = 9

N = 9

HR (bpm)

377 ± 11

379 ± 9

383 ± 11

407 ± 11

370 ± 12

387 ± 6

377 ± 10

391 ± 6

IVSd(mm)

1.5 ± 0.1

0.9 ± 0.1**

1.0 ± 0.01*

1.0 ± 0.1*

1.6 ± 0.1

0.8 ± 0.1**

1.0 ± 0.1*

0.8 ± 0.1**

LVIDd(mm)

7.7 ± 0.1

8.3 ± 0.3

8.4 ± 0.2

8.1 ± 0.3

8.0 ± 0.4

10.1 ± 0.3** §

9.7 ± 0.4** §

9.7 ± 0.2 ** §

LVPWd(mm)

1.8 ± 0.1

1.8 ± 0.1

1.9 ± 0.1

1.8 ± 0.1

2.1 ± 0.2

2.3 ± 0.2

2.0 ± 0.12

2.0 ± 0.1

IVSs(mm)

2.9 ± 0.1

1.3 ± 0.2*

2.0 ± 0.6

1.3 ± 0.2*

2.9 ± 0.2

1.0 ± 0.2**

1.2 ± 0.2**

1.2 ± 0.2**

LVIDs(mm)

4.2 ± 0.1

6.5 ± 0.3**

6.0 ± 0.4**

6.3 ± 0.3**

4.6 ± 0.4

8.6 ± 0.5** §

7.7 ± 0.4**

7.6 ± 0.2** §

LVPWs(mm)

2.9 ± 0.1

2.7 ± 0.1

2.6 ± 0.2

2.5 ± 0.1

2.9 ± 0.2

2.7 ± 0.3

2.6 ± 0.1

2.6 ± 0.2

LVEF (%)

82 ± 1

49 ± 3**

48 ± 4**

49 ± 3**

78 ± 3

36 ± 5** §

45 ± 5**

48 ± 4**

FS (%)

46 ± 2

22 ± 2**

21 ± 2**

22 ± 2**

43 ± 3

16 ± 3**§

21 ± 2**

22 ± 2**

  1. Data are presented as means ± SEM; N indicates number of animals; bpm, beats per minute. **P < 0.01 and *P < 0.05 indicate significant differences compared to sham-operated rats in week 3 and week 12 respectively; § P < 0.05 indicates significant difference between parameters at week 12 and week 3 using Paired-Sample T-Test. IVSd and IVSs, the thickness of the interventricular septum in diastole and systole; LVIDd and LVIDs, diastolic and systolic left ventricle dimensions; LVPWd and LVPWs, the thickness of left ventricle posterior wall in diastole and systole.
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Cardiovascular Diabetology

ISSN: 1475-2840