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Table 4 Hazard ratios for the significant association between ADIPOR2 SNPs and the development of CVD during follow-up of median 10.2 years

From: Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study

  

HR (95% CI), p/qa

HR, 95% CI, p/qb

rs10848554

GG (358)

1

1

 

GC (102)

1.510 (0.957-2.382), 0.076/0.110

1.565 (1.004-2.440), 0.048/0.095

 

CC (7)

2.919 (0.697-12.23), 0.143/0.150

 

rs11061937

TT (207)

1

1

 

TC (206)

0.568 (0.364-0.885), 0.012/0.095

0.595 (0.395-0.896), 0.013/0.095

 

CC (54)

0.701 (0.353-1.390), 0.309/0.238

 

rs1058322

CC (218)

1

1

 

CT (201)

1.601 (1.021-2.509), 0.040/0.095

1.711 (1.114-2.627), 0.014/0.095

 

TT (48)

2.300 (1.194-4.433), 0.013/0.095

 

rs16928751

GG (364)

1

1

 

GA (99)

1.677 (1.051-2.674), 0.030/0.095

1.756 (1.114-2.766), 0.015/0.095

 

AA (4)

4.425 (1.042-18.79), 0.044/0.095

 
  1. All analyses were adjusted for age, sex, baseline waist circumference, baseline 2-h plasma glucose and study group; Correction for multiple hypothesis testing in single SNP analyses was performed by using FDR, denoted as q-value; aAdditive inheritance model for single SNP analyses; bDominant inheritance model for single SNP analyses.
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Cardiovascular Diabetology

ISSN: 1475-2840