Association of ADIPOR2 gene variants with cardiovascular disease and type 2 diabetes risk in individuals with impaired glucose tolerance: the Finnish Diabetes Prevention Study

Table 2 Genotype counts and allele frequencies of ADIPOR2 SNPs in the DPS and Genobin study population

SNP and its location within gene						HWE
	Population	Genotype counts			MAF	p/q^a	p/q^b
rs10848554		GG	GC	CC	C
5' promoter region	DPS	373	104	7	0.122	0.934/0.389	0.401/0.204
	Genobin	44	12	0	0.107	0.369/0.377
rs11061937		TT	TC	CC	C
Intron 1	DPS	213	214	57	0.339	0.772/0.378	0.208/0.170
	Genobin	16	27	13	0.473	0.805/0.378
rs11061946		CC	CT	TT	T
Intron 1	DPS	430	49	5	0.061	0.011/0.377	0.042/0.170
	Genobin	48	8	0	0.071	0.565/0.377
rs1058322		CC	CT	TT	T
Intron 1	DPS	230	206	48	0.320	0.850/0.378	0.958/0.299
	Genobin	22	29	5	0.348	0.292/0.377
rs11061973		GG	GA	AA	A
Intron 2	DPS	403	76	5	0.089	0.508/0.377	0.027/0.170
	Genobin	44	12	0	0.107	0.369/0.377
rs4766415		AA	AT	TT	T
Intron 2	DPS	128	254	102	0.473	0.247/0.377	0.243/0.170
	Genobin	11	26	19	0.429	0.697/0.378
rs16928751		GG	GA	AA	A
Exon 7	DPS	379	101	4	0.113	0.331/0.377	0.493/0.206
	Genobin	47	9	0	0.080	0.513/0.377
rs1044471		CC	CT	TT	T
3' UTR	DPS	136	245	103	0.466	0.706/0.378	0.578/0.207
	Genobin	22	28	6	0.357	0.506/0.377

^ap/q value for Hardy-Weinberg equilibrium; ^bp/q value for differences in genotype frequencies between the study groups of DPS; Correction for multiple hypothesis testing was performed with FDR, denoted as q-value.

ISSN: 1475-2840