Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus

Poulsen, Mikael K; Nybo, Mads; Dahl, Jordi; Hosbond, Susanne; Poulsen, Tina S; Johansen, Allan; Høilund-Carlsen, Poul F; Beck-Nielsen, Henning; Rasmussen, Lars M; Henriksen, Jan E

doi:10.1186/1475-2840-10-76

Cardiovascular Diabetology

Table 3 Association between risk factors of cardiovascular disease and different cardiovascular disease manifestations

From: Plasma osteoprotegerin is related to carotid and peripheral arterial disease, but not to myocardial ischemia in type 2 diabetes mellitus

Carotid arterial disease
Co-variables		Univariate			Multivariate*
	Odds ratio	95% CI	p	Odds ratio	95% CI	P
Blood pressure, systolic (mmHg)	1.01	1.00-1.03	0.030	1.01	1.00-1.03	0.102
Blood pressure, diastolic (mmHg)	1.00	0.97-1.02	0.648	1.00	0.99-1.03	0.391
Total cholesterol (mmol/l)	0.98	0.79-1.22	0.861	1.00	0.79-1.26	0.998
LDL cholesterol (mmol/l)	1.01	0.77-1.33	0.930	1.07	0.80-1.44	0.627
HDL cholesterol (mmol/l)	1.55	0.80-3.02	0.195	0.81	0.38-1.72	0.590
Triclycerides (mmol/l)	0.89	0.74-1.08	0.238	0.97	0.80-1.18	0.741
Hs-CRP (mg/l)	1.00	0.97-1.03	0.890	1.00	0.97-1.03	0.827
Osteoprotegerin (μg/l)	3.37	2.02-5.65	< 0.001	2.12	1.22-3.67	0.008
Peripheral arterial disease
Co-variables		Univariate			Multivariate*
	Odds ratio	95% CI	p	Odds ratio	95% CI	P
Blood pressure, systolic (mmHg)	1.02	0.99-1.03	0.066	1.01	0.99-1.03	0.237
Blood pressure, diastolic (mmHg)	0.97	0.93-1.00	0.033	0.97	0.94-1.00	0.058
Total cholesterol (mmol/l)	0.99	0.72-1.34	0.929	0.99	0.72-1.35	0.935
LDL cholesterol (mmol/l)	0.85	0.57-1.27	0.420	0.86	0.58-1.28	0.454
HDL cholesterol (mmol/l)	1.76	0.75-4.16	0.197	1.29	0.48-3.44	0.617
Triclycerides (mmol/l)	1.01	0.79-1.29	0.926	1.08	0.84-1.39	0.552
Hs-CRP (mg/l)	1.01	0.97-1.05	0.578	1.01	0.97-1.04	0.746
Osteoprotegerin (μg/l)	2.78	1.65-4.68	< 0.001	1.77	0.97-3.22	0.063
Myocardial ischemia
Co-variables		Univariate			Multivariate*
	Odds ratio	95% CI	p	Odds ratio	95% CI	P
Blood pressure, systolic (mmHg)	1.01	0.99-1.02	0.119	1.01	1.00-1.03	0.132
Blood pressure, diastolic (mmHg)	1.02	0.99-1.04	0.166	1.01	0.99-1.03	0.395
Total cholesterol (mmol/l)	0.96	0.76-1.22	0.749	0.96	0.75-1.22	0.714
LDL cholesterol (mmol/l)	1.01	0.75-1.36	0.931	1.01	0.75-1.36	0.960
HDL cholesterol (mmol/l)	0.54	0.25-1.17	0.119	0.65	0.29-1.48	0.306
Triclycerides (mmol/l)	1.01	0.84-1.22	0.924	0.97	0.80-1.18	0.749
Hs-CRP (mg/l)	1.02	0.99-1.05	0.256	1.02	0.99-1.05	0.289
Osteoprotegerin (μg/l)	1.13	0.73-1.77	0.584	1.26	0.77-2.06	0.364

Data are odds ratios, 95% confidence intervals (CI), and p-values. The outcome variables are carotid arterial disease, peripheral arterial disease, and myocardial ischemia, respectively.
*Adjusted for age, HbA1c and U-albumin-creatinine ratio.

Back to article page

ISSN: 1475-2840

Contact us

Submission enquiries: journalsubmissions@springernature.com