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Table 1 The clinical characteristics of all patients, low vs. high risk patients and patients with significant coronary artery disease (CAD; abnormal MPI and/or stenosis on coronary angiography).

From: Osteoprotegerin and coronary artery disease in type 2 diabetic patients with microalbuminuria

  All patients
(n = 200)
Low-risk patients
(n = 67)
High-risk patients
(n = 133)
p-values1 Patients without sign. CAD
(n = 63)
Patients with sign. CAD
(n = 70)
p-values2
Sex no. (male%) 152 (76) 50(75) 102 (77) 0.747 14 (20) 56 (80) 0.33
Age (years) 59 (9) 53 (10) 61 (6) 0.001 57 (9) 62 (6) 0.001
Duration of diabetes (years) 13 (7) 10 (7) 14 (7) 0.001 12 (7) 15 (7) 0.006
BMI (kg/m2) 32.6 (5.8) 32.9 (6.0) 32.4 (5.7) 0.592 32.3 (5.8) 33.1 (5.7) 0.32
HbA1c (%) 7.9 (1.3) 8.0 (1.3) 7.8 (1.4) 0.194 7.8 (1.3) 7.8 (1.5) 0.80
Urinary albumin excretion rate (mg/24h)* 103 (39 - 230) 105 (44 - 194) 97 (38 - 97) 0.814 97 (43 - 194) 133 (38 - 491) 0.22
P-creatinine (μmol/l) 76 (18) 72 (17) 79 (19) 0.007 73 (17) 82 (20) 0.001
Systolic blood pressure (mmHg) 130 (17) 130 (16) 130 (18) 0.953 129 (17) 132 (18) 0.38
Total cholesterol (mmol/l) 3.9 (0.9) 4.1 (1.0) 3.8 (0.9) 0.041 4.0 (1.0) 3.8 (0.9) 0.08
Vibratory perception threshold mV - mean of both sides 33 (15) 28 (14) 36 (14) 0.001 30 (14) 39 (13) 0.001
Heart rate variation during deep breathing (bpm)* 7 (4.5-11.5) 9 (7-14) 6 (4-10) 0.001 8 (5-12) 6 (4-10) 0.013
Retinopathy no. (%) 120 (60) 28 (42) 92 (69) 0.001 71(55) 49 (70) 0.034
Oral antidiabetic medication no. (%) 170 (85) 57 (85) 113 (85) 0.98 111(85) 59 (84) 0.83
Insulin treatment no. (%) 124 (62) 38 (57) 86 (65) 0.28 77(59) 47 (67) 0.27
RAAS blockade no. (%) 196 (98) 65 (97) 131 (98) 0.48 127 (98) 69 (99) 0.67
Statin therapy no. (%) 189 (95) 62 (93) 127 (95) 0.39 122 (94) 67 (96) 0.58
Aspirin therapy no. (%) 183 (92) 58 (87) 125 (94) 0.076 119 (92) 69 (99) 0.98
Beta-blocker therapy no. (%) 27 (14) 2 (3) 25 (19) 0.002 12 (9) 15 (21) 0.016
Calcium channel blockers no. (%) 80 (40) 21 (31) 59 (44) 0.076 47 (36) 33 (47) 0.13
Use of diuretics no. (%) 128 (64) 35 (52) 93 (70) 0.014 82(63) 46(66) 0.71
Current smoker no. (%) 59 (30) 18 (27) 41 (31) 0.56 36(28) 23 (33) 0.45
NT-proBNP (ng/l) * 48.7 (18.6-95.0) 15.3 (9.3-26.3) 77.1 (48.7-141.7) nr 30.1 (13.4-77.1) 76.7 (52.8-139.5) 0.001
Coronary Calcium Score* 183 (6-604) 7 (0-104) 417 (80-963) nr 71 (1-272) 748 (177-1518) 0.001
  1. Data are expressed as means (SD) or * medians (interquartile range).
  2. high-risk patients = patients with plasma NT-proBNP levels >45.2 ng/l or plasma NT-proBNP levels ≤45.2 ng/l and CCS ≥400, all other low-risk patients.
  3. nr = not relevant.
  4. p-values reflect comparison 1) between high- and low risk patients and 2) patients with or without significant CAD.