Table 6 Relative changes in pro-angiogenic gene expression for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.
| Â | Â | WAT | BAT | ||
|---|---|---|---|---|---|
| Â | Â | eNOS-/- | DDAH | eNOS-/- | DDAH |
Pro - Angiogenic genes | |||||
MMP's | Â | Â | Â | Â | Â |
Stromielins |  | ↓ | ↓ |  |  |
basigin | Bsg |  |  |  | ↑ |
Gelatinases |  |  | ↓ |  |  |
matrix metallopeptidase | Mmp19 | ↑ |  |  |  |
|  | Mmp17 | ↑ |  |  |  |
Proliferation | Â | Â | Â | Â | Â |
Rho-associated coiled-coil containing protein kinase 1 | Rock1 | ↑ |  |  |  |
coatomer protein complex, subunit beta | Rack2 |  | ↓ |  |  |
myosin, light polypeptide kinase | Mylk | ↑ | ↓ |  |  |
proliferating cell nuclear antigen | Pcna |  |  |  | ↑ |
macrophage expressed gene 1 | Mpeg1 |  |  |  | ↑ |
cyclin H | CCnh |  |  |  | ↑ |
Jun oncogene | Jun |  |  | ↑ | ↓ |
FBJ osteosarcoma oncogene | Fos |  |  | ↑ | ↑ |
Cell survival | Â | Â | Â | Â | |
RAF proteins |  | ↑ | ↓ | ↑ |  |
ERK proteins |  | ↑ |  |  |  |
X-linked inhibitor of apoptosis | Birc4 |  | ↑ |  |  |
Jun oncogene | Jun |  |  | ↑ | ↓ |
Apoptosis |  |  | ↑ |  | |
heat shock protein | Hspa1a |  |  | ↑ |  |
Adhesion | Â | Â | Â | Â | |
platelet derived growth factor receptor, alpha | Pdgfra |  |  | ↑ |  |
fibronectin | Fn1 | ↑ |  |  |  |
tenascin XB | Tnxb | ↓ | ↓ |  |  |
von Willebrand factor | Vwf |  | ↓ |  |  |