Table 4 Relative changes in gene expression related to carbohydrate metabolism for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.
| Â | Â | WAT | BAT | ||
|---|---|---|---|---|---|
| Â | Â | eNOS-/- | DDAH | eNOS-/- | DDAH |
Insulin signaling | |||||
insulin receptor substrate | Irs1 |  |  | ↑ |  |
|  | Is3 |  |  |  | ↓ |
growth factor receptor bound protein 2-associated protein 1 | Gab1 |  |  |  | ↓ |
phosphatidylinositol 3-kinase | PIk3r1 | ↓ | ↓ |  | ↑ |
|  | PIk3r2 | ↑ |  |  |  |
|  | PIk3ca |  | ↓ |  |  |
phosphatase and tensin homolog | Pten | ↓ | ↓ |  |  |
integrin linked kinase | Ilk | ↑ |  |  |  |
actinin | Actn | ↑ |  |  |  |
vinculin | Vcl |  | ↑ |  |  |
filamin | Flna | ↑ | ↓ |  |  |
zyxin | Zyx | ↑ |  |  |  |
vasodilator-stimulated phosphoprotein | Vasp | ↑ |  |  |  |
RAS-related C3 botulinum substrate 1 | Rac1 |  | ↑ |  |  |
AKT/PDK | |||||
thymoma viral proto-oncogene 2 | Akt2 | ↑ |  |  |  |
serum/glucocorticoid regulated kinase | Sgk |  | ↓ | ↑ |  |
glycogen synthase kinase 3 beta | Gsk3b | ↑ |  |  | ↓ |
m-TOR | |||||
tuberous sclerosis | Tsc1 |  |  |  | ↓ |
|  | Tsc2 | ↑ |  |  |  |
mechanistic target of rapamycin (serine/threonine kinase) | frap1 |  |  |  | ↓ |
ribosomal protein S6 kinase | Rps6kb1 | ↑ |  |  | ↑ |
|  | Rps6kb2 | ↓ |  |  |  |
eukaryotic translation initiation factor 4E binding protein | Eif4ebp1 |  |  |  | ↓ |
Glycolysis/Gluconeogenesis | |||||
enolase | Eno3 | ↑# |  |  | ↓ |
glucose phosphate isomerase 1 | Gpi1 | ↑ |  |  | ↓ |
aldolase | Aldoa | ↑ |  |  | ↓ |