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Table 3 Relative changes in gene expression related to lipid metabolism for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.

From: Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

   WAT BAT
   eNOS-/- DDAH eNOS-/- DDAH
Lipodystrophy related genes     
lipin Lipin1   
lysophosphatidic acid acyltransferase, beta Agpat2   
zinc metallopeptidase Zmpste24     
Bernardinelli-Seip congenital lipodystrophy Bscl2    
Cholesterol synthesis
hydroxymethylglutaryl-CoA synthase 1 Hmgcs1   
farnesyl diphosphate synthetase Fdps    
phosphomevalonate kinase Pmvk    
mevalonate kinase Mvk   
squalene epoxidase Sqle   
7-dehydrocholesterol reductase Dhcr7  
lanosterol synthase Lss    
cytochrome P450, family 51 Cyp51    
sterol-C5-desaturase Sc5d    
Triglyceride synthesis
diacylglycerol O-acyltransferase Dgat1     
  Dgat2    
lysophosphatidic acid acyltransferase, beta Agpat2    
Fatty acid synthesis
fatty acid synthase Fasn # ↓#   ↓#
stearoyl-Coenzyme A desaturase Scd    
ATP citrate lyase Acly    
acetyl-Coenzyme A carboxylase beta Acacb
mitochondrial trans-2-enoyl-CoA reductase Nrbf1    
enoyl coenzyme A hydratase 1 Ech1    
Fatty acid beta-oxydation
patatin-like phospholipase domain containing 2 Pnpla2    
mitochondrial trifunctional protein, alpha subunit Hadha    
fatty acid Coenzyme A ligase Acsl1     
  Acsl3    
  Acsl5    
carnitine palmitoyltransferase 1a Cpt1a    
acyl-Coenzyme A dehydrogenase Acads    
  Acadvl    
mitochondrial carnitine/acylcarnitine translocase Slc25a20    
triosephosphate isomerase 1 Tpi1    
glycerol kinase Gyk    
carnitine acetyltransferase Crat    
carnitine palmitoyltransferase 2 Cpt2    
carnitine palmitoyltransferase 1b Cpt1b    
  1. ↑ - upregulated genes; ↓ -downregulated genes; # - genes which expression was confirmed by real time PCR