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Table 3 Relative changes in gene expression related to lipid metabolism for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.

From: Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

  

WAT

BAT

  

eNOS-/-

DDAH

eNOS-/-

DDAH

Lipodystrophy related genes

    

lipin

Lipin1

↑

  

↓

lysophosphatidic acid acyltransferase, beta

Agpat2

↑

  

↓

zinc metallopeptidase

Zmpste24

 

↓

  

Bernardinelli-Seip congenital lipodystrophy

Bscl2

   

↓

Cholesterol synthesis

hydroxymethylglutaryl-CoA synthase 1

Hmgcs1

↑

↑

  

farnesyl diphosphate synthetase

Fdps

 

↑

↓

 

phosphomevalonate kinase

Pmvk

   

↓

mevalonate kinase

Mvk

↑

↑

  

squalene epoxidase

Sqle

  

↓

↓

7-dehydrocholesterol reductase

Dhcr7

↑

↑

 

↓

lanosterol synthase

Lss

 

↑

  

cytochrome P450, family 51

Cyp51

 

↑

  

sterol-C5-desaturase

Sc5d

 

↑

  

Triglyceride synthesis

diacylglycerol O-acyltransferase

Dgat1

 

↓

  
 

Dgat2

↑

   

lysophosphatidic acid acyltransferase, beta

Agpat2

↑

   

Fatty acid synthesis

fatty acid synthase

Fasn

↑#

↓#

 

↓#

stearoyl-Coenzyme A desaturase

Scd

 

↑

  

ATP citrate lyase

Acly

↑

 

↓

 

acetyl-Coenzyme A carboxylase beta

Acacb

↓

↓

↓

↓

mitochondrial trans-2-enoyl-CoA reductase

Nrbf1

↓

   

enoyl coenzyme A hydratase 1

Ech1

   

↓

Fatty acid beta-oxydation

patatin-like phospholipase domain containing 2

Pnpla2

↓

   

mitochondrial trifunctional protein, alpha subunit

Hadha

 

↓

 

↓

fatty acid Coenzyme A ligase

Acsl1

  

↓

 
 

Acsl3

   

↓

 

Acsl5

↓

   

carnitine palmitoyltransferase 1a

Cpt1a

 

↑

  

acyl-Coenzyme A dehydrogenase

Acads

   

↓

 

Acadvl

   

↓

mitochondrial carnitine/acylcarnitine translocase

Slc25a20

   

↓

triosephosphate isomerase 1

Tpi1

   

↓

glycerol kinase

Gyk

   

↓

carnitine acetyltransferase

Crat

   

↓

carnitine palmitoyltransferase 2

Cpt2

   

↓

carnitine palmitoyltransferase 1b

Cpt1b

   

↓

  1. ↑ - upregulated genes; ↓ -downregulated genes; # - genes which expression was confirmed by real time PCR