|  | WAT | BAT | ||
---|---|---|---|---|---|
 |  | eNOS-/- | DDAH | eNOS-/- | DDAH |
Lipodystrophy related genes | Â | Â | Â | Â | |
lipin | Lipin1 | ↑ |  |  | ↓ |
lysophosphatidic acid acyltransferase, beta | Agpat2 | ↑ |  |  | ↓ |
zinc metallopeptidase | Zmpste24 |  | ↓ |  |  |
Bernardinelli-Seip congenital lipodystrophy | Bscl2 |  |  |  | ↓ |
Cholesterol synthesis | |||||
hydroxymethylglutaryl-CoA synthase 1 | Hmgcs1 | ↑ | ↑ |  |  |
farnesyl diphosphate synthetase | Fdps |  | ↑ | ↓ |  |
phosphomevalonate kinase | Pmvk |  |  |  | ↓ |
mevalonate kinase | Mvk | ↑ | ↑ |  |  |
squalene epoxidase | Sqle |  |  | ↓ | ↓ |
7-dehydrocholesterol reductase | Dhcr7 | ↑ | ↑ |  | ↓ |
lanosterol synthase | Lss |  | ↑ |  |  |
cytochrome P450, family 51 | Cyp51 |  | ↑ |  |  |
sterol-C5-desaturase | Sc5d |  | ↑ |  |  |
Triglyceride synthesis | |||||
diacylglycerol O-acyltransferase | Dgat1 |  | ↓ |  |  |
 | Dgat2 | ↑ |  |  |  |
lysophosphatidic acid acyltransferase, beta | Agpat2 | ↑ |  |  |  |
Fatty acid synthesis | |||||
fatty acid synthase | Fasn | ↑# | ↓# |  | ↓# |
stearoyl-Coenzyme A desaturase | Scd |  | ↑ |  |  |
ATP citrate lyase | Acly | ↑ |  | ↓ |  |
acetyl-Coenzyme A carboxylase beta | Acacb | ↓ | ↓ | ↓ | ↓ |
mitochondrial trans-2-enoyl-CoA reductase | Nrbf1 | ↓ |  |  |  |
enoyl coenzyme A hydratase 1 | Ech1 |  |  |  | ↓ |
Fatty acid beta-oxydation | |||||
patatin-like phospholipase domain containing 2 | Pnpla2 | ↓ |  |  |  |
mitochondrial trifunctional protein, alpha subunit | Hadha |  | ↓ |  | ↓ |
fatty acid Coenzyme A ligase | Acsl1 |  |  | ↓ |  |
 | Acsl3 |  |  |  | ↓ |
 | Acsl5 | ↓ |  |  |  |
carnitine palmitoyltransferase 1a | Cpt1a |  | ↑ |  |  |
acyl-Coenzyme A dehydrogenase | Acads |  |  |  | ↓ |
 | Acadvl |  |  |  | ↓ |
mitochondrial carnitine/acylcarnitine translocase | Slc25a20 |  |  |  | ↓ |
triosephosphate isomerase 1 | Tpi1 |  |  |  | ↓ |
glycerol kinase | Gyk |  |  |  | ↓ |
carnitine acetyltransferase | Crat |  |  |  | ↓ |
carnitine palmitoyltransferase 2 | Cpt2 |  |  |  | ↓ |
carnitine palmitoyltransferase 1b | Cpt1b |  |  |  | ↓ |