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Table 2 Relative changes in gene expression connected with adipogenesis for white (WAT) and brown (BAT) adipose tissues of eNOS -/- and DDAH animals vs. control mice.

From: Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance

  

WAT

BAT

  

eNOS-/-

DDAH

eNOS-/-

DDAH

Adipogenesis

CCAAT/enhancer binding protein (C/EBP)

Cebpa

↑

  

↓

 

Cebpb

↑

  

↓

 

Cabpd

  

↑

 

peroxisome proliferator activated receptor alpha

Ppara

 

↓

 

↓

peroxisome proliferator-activated receptor gamma

Pparg

 

↓ #

  

peroxisome proliferator-activated receptor beta

Pparb

↑

   

retinoid X receptor gamma

Rxrg

 

↓

  

forkhead box O

Foxo1

↑

↑

 

↓

 

Foxo3a

   

↓

myocyte enhancer factor

Mef2c

 

↓

  
 

Mef2d

↑

  

↓

nuclear receptor subfamily 2, group F, member 1

Nr2f1

↑

   

nuclear receptor interacting protein

Nrip

↓

↓

 

↑

nuclear receptor co-repressor

Ncor

↑

   

transforming growth factor, beta

Tgfb

↑

   

insulin-like growth factor 1

Igf1

   

↑

Kruppel-like factor 6

Klf6

 

↓

↑

 

Kruppel-like factor 7

Klf7

  

↑

 

nuclear receptor subfamily 3, group C, member 1

Nr3C1

 

↓

  

prolactin receptor

Prlr

↓

   

early B-cell factor 1

Ebf1

↓

   

growth differentiation factor 10

Gdf10

↑

↓

  

catenin (cadherin associated protein)

Catnb

 

↑

 

↑

early growth response

Egr

 

↑

  

zinc finger, HIT type 3

Trip3

   

↑

stearoyl-Coenzyme A desaturase 1

Scd1

 

↑

  

inhibitor of DNA binding 3

Id3

  

↑

 

phosphoenolpyruvate carboxykinase 1, cytosolic

Pck1

   

↑

interleukin 6 signal transducer

Il6st

   

↓

Adipocyte differentiation markers

    

fatty acid binding protein 4

Fabp4

↓

↓ #

↑

 

uncoupling protein 1

Ucp1

↑#

↓ #

 

↓ #

lipoprotein lipase

LPL

 

↓ #

 

↓ #

lipase, hormone sensitive

Lipe

 

↓

↓

 

facilitated glucose transporter

Glut4

↑#

 

↓ #

 

Adipocyte secretion products

    

angiotensinogen

Agt

↓

↓

  

adipsin

Adn

   

↓

adipophilin

Adfp

   

↓

  1. ↑ - upregulated genes; ↓ - downregulated genes; # - genes which expression was confirmed by real time PCR