Figure 3

Insulin sensitivity of C57BL/6J (n = 19), eNOS-/- (n = 16) and DDAH (n = 24) mice. Insulin sensitivity was shown at baseline and after 13 weeks of feeding with a high saturated fat diet. Values are expressed as means ± SEM, *p < 0.05; **p < 0.01, significance between baseline and 13 weeks of feeding with a high fat diet. (A) Quantitative insulin sensitivity check index (QUICKI) (baseline and after 13 weeks of high fat diet feeding). QUICKI = 1/[log(I) + log(G), where I is fasting insulin (mU/l) and G is fasting glucose (mg/dl). (B) Homeostasis model assessment (HOMA) (baseline and after 13 weeks of high fat diet feeding). HOMA = G * I/22,5, where I is fasting insulin (mU/l) and G is fasting glucose (mmol/l).