TY - JOUR AU - Razny, Urszula AU - Kiec-Wilk, Beata AU - Wator, Lukasz AU - Polus, Anna AU - Dyduch, Grzegorz AU - Solnica, Bogdan AU - Malecki, Maciej AU - Tomaszewska, Romana AU - Cooke, John P. AU - Dembinska-Kiec, Aldona PY - 2011 DA - 2011/07/22 TI - Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance JO - Cardiovascular Diabetology SP - 68 VL - 10 IS - 1 AB - High fat diet impairs nitric oxide (NO) bioavailability, and induces insulin resistance. The link between NO availability and the metabolic adaptation to a high fat diet is not well characterized. The purpose of this study was to investigate the effect of high fat diet on metabolism in mice with decreased (eNOS-/-) and increased (DDAH overexpressed) NO bioavailability. SN - 1475-2840 UR - https://doi.org/10.1186/1475-2840-10-68 DO - 10.1186/1475-2840-10-68 ID - Razny2011 ER -