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Table 3 Fasting hepatic glucose production, insulin-stimulated whole body glucose uptake, insulin-inhibited hepatic glucose production and plasma concentrations of metabolites and insulin in diabetic pigs fed saturated fat/cholesterol or unsaturated fat or starch enriched diets

From: Dietary saturated fat/cholesterol, but not unsaturated fat or starch, induces C-reactive protein associated early atherosclerosis and ectopic fat deposition in diabetic pigs

  Saturated fat plus cholesterol diet Unsaturated fat diet Starch diet
Fasting plasma fructosamine (μmol/L) 449 ± 25 494 ± 62 558 ± 103
Fasting plasma glucose (mmol/L) 12.4 ± 0.4 14.4 ± 0.7 12.7 ± 1.6
Fasting plasma insulin (pmol/L) 23 ± 7 26 ± 7 22 ± 4
Fasting hepatic glucose production (mg.kg -1 .min -1 ) 7.4 ± 0.8 6.4 ± 0.5 8.2 ± 2.0
Clamp plasma glucose (steady state, mmol/L) 5.7 ± 0.2 5.4 ± 0.2 5.4 ± 0.2
Clamp plasma insulin (steady state, pmol/L) 320 ± 27 409 ± 33 327 ± 33
Insulin-stimulated whole body glucose uptake (mg.kg -1 .min -1 ) 10.0 ± 2.3 9.5 ± 2.1 10.8 ± 2.8
Insulin-inhibited hepatic glucose production
(mg.kg -1 .min -1 )
1.8 ± 0.2 1.2 ± 0.3 1.8 ± 0.1