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Figure 3 | Cardiovascular Diabetology

Figure 3

From: Glucagon-like peptide-1 enhances cardiac L-type Ca2+ currents via activation of the cAMP-dependent protein kinase A pathway

Figure 3

Intracellular dialysis of PKA-I (PKA-I fragment 4-25, 5 μM) prevented the GLP-1-induced enhancement of I Ca in isolated canine left ventricular myocytes (n = 5). Ca2+ currents were evoked by the depolarizing pulses from -40 mV to 0 mV every 10 s. Control, ICa was recorded immediately after forming the whole-cell configuration; PKA-I, ICa was recorded at 20 min after forming the whole-cell configuration and PKA-I dialysis; PKA-I+GLP-1, ICa was recorded at 35 min after PKA-I dialysis and 15 min after GLP-1 perfusion.

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