C57Bl/6J | LDLR-/-ApoB100/100 | IGF-II/LDLR-/-ApoB100/100 | |
---|---|---|---|
Metabolic parameters | |||
Body weight (g) | |||
Females | 34.4 ± 6.5 | 28.8 ± 1.9 | 33.3 ± 3.1 |
Males | 45.8 ± 5.6‡ | 35.4 ± 4.2*‡ | 36.8 ± 3.7 |
Glucose (mmol/l) | 3.5 ± 0.8 | 5.2 ± 1.0 | 8.2 ± 3.0*† |
Cholesterol (mmol/l) | 3.9 ± 1.4 | 25.5 ± 7.9* | 27.8 ± 5.0* |
Triglycerides (mmol/l) | 1.0 ± 0.3 | 1.1 ± 0.3 | 1.5 ± 0.5*† |
Echocardiographic measurements in baseline | |||
HR (bpm) | 443.5 ± 41.0 | 504.8 ± 14.1* | 486.1 ± 30.1* |
Dimensions | |||
LVIDED (mm) | 3.45 ± 0.38 | 4.13 ± 0.61* | 4.09 ± 0.38* |
LVIDES (mm) | 2.3 ± 0.44 | 3.25 ± 0.80* | 3.14 ± 0.51* |
LVPW;d (mm) | 1.26 ± 0.27 | 0.88 ± 0.18* | 0.90 ± 0.18* |
LVPW;s (mm) | 1.70 ± 0.34 | 1.13 ± 0.24* | 1.15 ± 0.26* |
LVAW;d (mm) | 1.22 ± 0.17 | 0.95 ± 0.17* | 1.04 ± 0.13* |
LVAW;s (mm) | 1.77 ± 0.22 | 1.18 ± 0.25* | 1.39 ± 0.22* |
LV Vol;d (μl) | 49.88 ± 12.34 | 77.88 ± 26.49* | 71.11 ± 12.43* |
LV Vol;s (μl) | 14.22 ± 7.32 | 46.23 ± 27.07* | 37.59 ± 13.37* |
LV Mass/Body weight | 4.42 ± 0.69 | 4.73 ± 1.58 | 4.10 ± 0.78 |
Systolic function | |||
EF (%) | 72.98 ± 9.45 | 44.86 ± 14.70* | 48.17 ± 11.06* |
FS (%) | 41.74 ± 7.72 | 22.46 ± 8.23* | 26.83 ± 10.73* |
Myocardial perfusion (ratio to C57Bl/6J) | |||
LVAW | 1.00 ± 0.06 | 0.97 ± 0.09 | 0.93 ± 0.19 |