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Table 1 Metabolic parameters, echocardiographic measurements and myocardial perfusion.

From: Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

 

C57Bl/6J

LDLR-/-ApoB100/100

IGF-II/LDLR-/-ApoB100/100

Metabolic parameters

Body weight (g)

   Females

34.4 ± 6.5

28.8 ± 1.9

33.3 ± 3.1

   Males

45.8 ± 5.6

35.4 ± 4.2*

36.8 ± 3.7

Glucose (mmol/l)

3.5 ± 0.8

5.2 ± 1.0

8.2 ± 3.0*

Cholesterol (mmol/l)

3.9 ± 1.4

25.5 ± 7.9*

27.8 ± 5.0*

Triglycerides (mmol/l)

1.0 ± 0.3

1.1 ± 0.3

1.5 ± 0.5*

Echocardiographic measurements in baseline

HR (bpm)

443.5 ± 41.0

504.8 ± 14.1*

486.1 ± 30.1*

Dimensions

   LVIDED (mm)

3.45 ± 0.38

4.13 ± 0.61*

4.09 ± 0.38*

   LVIDES (mm)

2.3 ± 0.44

3.25 ± 0.80*

3.14 ± 0.51*

   LVPW;d (mm)

1.26 ± 0.27

0.88 ± 0.18*

0.90 ± 0.18*

   LVPW;s (mm)

1.70 ± 0.34

1.13 ± 0.24*

1.15 ± 0.26*

   LVAW;d (mm)

1.22 ± 0.17

0.95 ± 0.17*

1.04 ± 0.13*

   LVAW;s (mm)

1.77 ± 0.22

1.18 ± 0.25*

1.39 ± 0.22*

   LV Vol;d (μl)

49.88 ± 12.34

77.88 ± 26.49*

71.11 ± 12.43*

   LV Vol;s (μl)

14.22 ± 7.32

46.23 ± 27.07*

37.59 ± 13.37*

   LV Mass/Body weight

4.42 ± 0.69

4.73 ± 1.58

4.10 ± 0.78

Systolic function

   EF (%)

72.98 ± 9.45

44.86 ± 14.70*

48.17 ± 11.06*

   FS (%)

41.74 ± 7.72

22.46 ± 8.23*

26.83 ± 10.73*

Myocardial perfusion

(ratio to C57Bl/6J)

   LVAW

1.00 ± 0.06

0.97 ± 0.09

0.93 ± 0.19

  1. Values denote mean ± SD of 12-15 C57Bl/6J mice, 9-12 LDLR-/-ApoB100/100 mice and 10-14 IGF-II/LDLR-/-ApoB100/100 mice. Metabolic parameters represent values after overnight fasting. Glucose was measured from whole blood. Cholesterol and triglycerides were analyzed from plasma. Cardiac measurements were obtained from echocardiography. Perfusion was measured with contrast pulse sequence ultrasound. HR, heart rate; LV, left ventricle; ID, internal diameter; ED, end-diastole; ES, end-systole; s, systole; d, diastole; PW, posterior wall; AW, anterior wall; Vol, volume; EF, ejection fraction; FS, fractional shortening.
  2. *P < 0.05 vs. C57Bl/6J
  3. P < 0.05 vs. LDLR-/-ApoB100/100
  4. P < 0.05 vs. females of the same strain