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Table 1 Metabolic parameters, echocardiographic measurements and myocardial perfusion.

From: Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

  C57Bl/6J LDLR-/-ApoB100/100 IGF-II/LDLR-/-ApoB100/100
Metabolic parameters
Body weight (g)
   Females 34.4 ± 6.5 28.8 ± 1.9 33.3 ± 3.1
   Males 45.8 ± 5.6 35.4 ± 4.2* 36.8 ± 3.7
Glucose (mmol/l) 3.5 ± 0.8 5.2 ± 1.0 8.2 ± 3.0*
Cholesterol (mmol/l) 3.9 ± 1.4 25.5 ± 7.9* 27.8 ± 5.0*
Triglycerides (mmol/l) 1.0 ± 0.3 1.1 ± 0.3 1.5 ± 0.5*
Echocardiographic measurements in baseline
HR (bpm) 443.5 ± 41.0 504.8 ± 14.1* 486.1 ± 30.1*
Dimensions
   LVIDED (mm) 3.45 ± 0.38 4.13 ± 0.61* 4.09 ± 0.38*
   LVIDES (mm) 2.3 ± 0.44 3.25 ± 0.80* 3.14 ± 0.51*
   LVPW;d (mm) 1.26 ± 0.27 0.88 ± 0.18* 0.90 ± 0.18*
   LVPW;s (mm) 1.70 ± 0.34 1.13 ± 0.24* 1.15 ± 0.26*
   LVAW;d (mm) 1.22 ± 0.17 0.95 ± 0.17* 1.04 ± 0.13*
   LVAW;s (mm) 1.77 ± 0.22 1.18 ± 0.25* 1.39 ± 0.22*
   LV Vol;d (μl) 49.88 ± 12.34 77.88 ± 26.49* 71.11 ± 12.43*
   LV Vol;s (μl) 14.22 ± 7.32 46.23 ± 27.07* 37.59 ± 13.37*
   LV Mass/Body weight 4.42 ± 0.69 4.73 ± 1.58 4.10 ± 0.78
Systolic function
   EF (%) 72.98 ± 9.45 44.86 ± 14.70* 48.17 ± 11.06*
   FS (%) 41.74 ± 7.72 22.46 ± 8.23* 26.83 ± 10.73*
Myocardial perfusion
(ratio to C57Bl/6J)
   LVAW 1.00 ± 0.06 0.97 ± 0.09 0.93 ± 0.19
  1. Values denote mean ± SD of 12-15 C57Bl/6J mice, 9-12 LDLR-/-ApoB100/100 mice and 10-14 IGF-II/LDLR-/-ApoB100/100 mice. Metabolic parameters represent values after overnight fasting. Glucose was measured from whole blood. Cholesterol and triglycerides were analyzed from plasma. Cardiac measurements were obtained from echocardiography. Perfusion was measured with contrast pulse sequence ultrasound. HR, heart rate; LV, left ventricle; ID, internal diameter; ED, end-diastole; ES, end-systole; s, systole; d, diastole; PW, posterior wall; AW, anterior wall; Vol, volume; EF, ejection fraction; FS, fractional shortening.
  2. *P < 0.05 vs. C57Bl/6J
  3. P < 0.05 vs. LDLR-/-ApoB100/100
  4. P < 0.05 vs. females of the same strain