Representative images of ultrastructural changes found in LDLR-/-ApoB100/100 and IGF-II/LDLR-/-ApoB100/100 mice. A) On the left, impaired cytoarchitecture with increased interfibrillar space, dense bodies (db) and polymorphic and often doughnut-like mitochondria (am, abnormal mitochondria). Note autophagosome (a) in the preserved area. Nm, normal mitochondria; m, myofiber. B) Detail of the damaged area with increased number of enlarged abnormal mitochondria (am), lysosomes (l) and sparse glycogen deposits (g). C) Increased interfibrillar space filled with autophagosomes (a), dense bodies (db), collagen fibrils (cf) and glycogen deposits (g). D) Detail on myelin figures (mf) and glycogen deposits (g). Images are from IGF-II/LDLR-/-ApoB100/100 mice. Bars 1.0 μm (A, B), 0.2 μm (C) and 0.5 μm (D).