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Figure 4 | Cardiovascular Diabetology

Figure 4

From: Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

Figure 4

Dobutamine stress echocardiography. M-mode short-axis views of the left mid-ventricle before and after β-adrenergic stimulation with dobutamine in an 18-month-old A) C57Bl/6J, B) IGF-II/LDLR-/-ApoB100/100 and C) LDLR-/-ApoB100/100 mouse. Compared to the C57Bl/6J control, IGF-II/LDLR-/-ApoB100/100 and LDLR-/-ApoB100/100 mice show reduced contractility. D) Regional wall motion analysis represents improvement of systolic function after dobutamine in all mouse strains, although statistically significant only in LDLR-/-ApoB100/100 mice. Results are mean ± SD of 5 (LDLR-/-ApoB100/100 and IGF-II/LDLR-/-ApoB100/100) or 6 animals (C57Bl/6J).

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Cardiovascular Diabetology

ISSN: 1475-2840