Evaluation of aortic atherosclerosis and vascular remodeling. A) Cross-sectional lesion areas from the aortic sinus level, B) calcification of atherosclerotic plaques and C) average absolute vessel (white bars) and lesion areas (black bars) in the aortic sinus (mean ± SD) of 18-month-old mice. In comparison to C57Bl/6J controls (n = 8), compensatory enlargement of vessel area is seen in LDLR-/-ApoB100/100 (n = 9) and IGF-II/LDLR-/-ApoB100/100 mice (n = 11) with vascular remodeling ratios in parenthesis indicating positive remodeling (> 1.05) in response to atherosclerosis. * P < 0.05 versus C57Bl/6J. D) Representative hematoxylin-eosin stained aortic sections from sinus level of C57Bl/6J (left panel), LDLR-/-ApoB100/100 (middle) and IGF-II/LDLR-/-ApoB100/100 mice (right panel). Original magnification × 40, scale bar 100 μm.