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Figure 1 | Cardiovascular Diabetology

Figure 1

From: Molecular role of GATA binding protein 4 (GATA-4) in hyperglycemia-induced reduction of cardiac contractility

Figure 1

Cardiac output and cardiac GATA-4 phosphorylation and troponin I expression in the heart. Comparison of streptozotocin-induced diabetic rats (STZ) and normal (Wistar) rats. Each column shows the mean ± SEM (n = 6). ***P < 0.001 (A). STZ diabetic rats were treated with insulin or phlorizin at a dose sufficient to correct the blood sugar level for 4 days. Then, rats were sacrificed and nuclear GATA-4 phosphorylation (B) and troponin I expression (C) were detected by Western blot analysis. The results are presented as the mean ± SEM (n = 6 per group). *P < 0.05 and **P < 0.01 as compared with the STZ rats.

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Cardiovascular Diabetology

ISSN: 1475-2840